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BIOMARKER:
ATM mutation
i
Other names:
ATM, ATA, ATC, ATD, ATDC, TEL1, TELO1, ATM serine/threonine kinase
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Entrez ID:
472
Related biomarkers:
Expression
Mutation
CNA
Others
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Related tests:
FoundationOne® CDx (110)
FoundationOne® Liquid CDx (21)
FoundationOne® CDx (110)
FoundationOne® Liquid CDx (21)
Associations
News
Trials
VERI cancer hierarchy
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ATM mutation
Prostate Cancer
ATM mutation
Prostate Cancer
olaparib
Sensitive: A1 - Approval
olaparib
Sensitive
:
A1
olaparib
Sensitive: A1 - Approval
olaparib
Sensitive
:
A1
ATM mutation
Squamous Cell Carcinoma of Head and Neck
ATM mutation
Squamous Cell Carcinoma of Head and Neck
durvalumab + tremelimumab
Sensitive: B - Late Trials
durvalumab + tremelimumab
Sensitive
:
B
durvalumab + tremelimumab
Sensitive: B - Late Trials
durvalumab + tremelimumab
Sensitive
:
B
ATM mutation
Breast Cancer
ATM mutation
Breast Cancer
ribociclib
Resistant: B - Late Trials
ribociclib
Resistant
:
B
ribociclib
Resistant: B - Late Trials
ribociclib
Resistant
:
B
ATM mutation
Chronic Lymphocytic Leukemia
ATM mutation
Chronic Lymphocytic Leukemia
obinutuzumab
Resistant: B - Late Trials
obinutuzumab
Resistant
:
B
obinutuzumab
Resistant: B - Late Trials
obinutuzumab
Resistant
:
B
ATM mutation
Ovarian Cancer
ATM mutation
Ovarian Cancer
olaparib
Sensitive: B - Late Trials
olaparib
Sensitive
:
B
olaparib
Sensitive: B - Late Trials
olaparib
Sensitive
:
B
ATM mutation
Solid Tumor
ATM mutation
Solid Tumor
Immunotherapy
Sensitive: B - Late Trials
Immunotherapy
Sensitive
:
B
Immunotherapy
Sensitive: B - Late Trials
Immunotherapy
Sensitive
:
B
ATM mutation
Prostate Cancer
ATM mutation
Prostate Cancer
rucaparib
Sensitive: B - Late Trials
rucaparib
Sensitive
:
B
rucaparib
Sensitive: B - Late Trials
rucaparib
Sensitive
:
B
ATM mutation
Chronic Lymphocytic Leukemia
ATM mutation
Chronic Lymphocytic Leukemia
zanubrutinib
Sensitive: B - Late Trials
zanubrutinib
Sensitive
:
B
zanubrutinib
Sensitive: B - Late Trials
zanubrutinib
Sensitive
:
B
ATM mutation
Lung Adenocarcinoma
ATM mutation
Lung Adenocarcinoma
olaparib
Sensitive: C1 - Off-label
olaparib
Sensitive
:
C1
olaparib
Sensitive: C1 - Off-label
olaparib
Sensitive
:
C1
ATM mutation
Pancreatic Cancer
ATM mutation
Pancreatic Cancer
olaparib
Sensitive: C1 - Off-label
olaparib
Sensitive
:
C1
olaparib
Sensitive: C1 - Off-label
olaparib
Sensitive
:
C1
ATM mutation
Pancreatic Ductal Adenocarcinoma
ATM mutation
Pancreatic Ductal Adenocarcinoma
olaparib
Sensitive: C1 - Off-label
olaparib
Sensitive
:
C1
olaparib
Sensitive: C1 - Off-label
olaparib
Sensitive
:
C1
ATM mutation
Urothelial Cancer
ATM mutation
Urothelial Cancer
olaparib
Sensitive: C1 - Off-label
olaparib
Sensitive
:
C1
olaparib
Sensitive: C1 - Off-label
olaparib
Sensitive
:
C1
ATM mutation
Biliary Tract Cancer
ATM mutation
Biliary Tract Cancer
olaparib
Sensitive: C1 - Off-label
olaparib
Sensitive
:
C1
olaparib
Sensitive: C1 - Off-label
olaparib
Sensitive
:
C1
ATM mutation
Solid Tumor
ATM mutation
Solid Tumor
rucaparib
Sensitive: C2 – Inclusion Criteria
rucaparib
Sensitive
:
C2
rucaparib
Sensitive: C2 – Inclusion Criteria
rucaparib
Sensitive
:
C2
ATM mutation
Prostate Cancer
ATM mutation
Prostate Cancer
talazoparib
Sensitive: C2 – Inclusion Criteria
talazoparib
Sensitive
:
C2
talazoparib
Sensitive: C2 – Inclusion Criteria
talazoparib
Sensitive
:
C2
ATM mutation
HER2 Negative Breast Cancer
ATM mutation
HER2 Negative Breast Cancer
durvalumab
Sensitive: C2 – Inclusion Criteria
durvalumab
Sensitive
:
C2
durvalumab
Sensitive: C2 – Inclusion Criteria
durvalumab
Sensitive
:
C2
ATM mutation
Solid Tumor
ATM mutation
Solid Tumor
avelumab
Sensitive: C2 – Inclusion Criteria
avelumab
Sensitive
:
C2
avelumab
Sensitive: C2 – Inclusion Criteria
avelumab
Sensitive
:
C2
ATM mutation
Solid Tumor
ATM mutation
Solid Tumor
APG-115
Sensitive: C2 – Inclusion Criteria
APG-115
Sensitive
:
C2
APG-115
Sensitive: C2 – Inclusion Criteria
APG-115
Sensitive
:
C2
ATM mutation
Biliary Tract Cancer
ATM mutation
Biliary Tract Cancer
toripalimab-tpzi
Resistant: C3 – Early Trials
toripalimab-tpzi
Resistant
:
C3
toripalimab-tpzi
Resistant: C3 – Early Trials
toripalimab-tpzi
Resistant
:
C3
ATM mutation
Colorectal Cancer
ATM mutation
Colorectal Cancer
niraparib
Sensitive: C3 – Early Trials
niraparib
Sensitive
:
C3
niraparib
Sensitive: C3 – Early Trials
niraparib
Sensitive
:
C3
ATM mutation
Solid Tumor
ATM mutation
Solid Tumor
BAY 1895344
Sensitive: C3 – Early Trials
BAY 1895344
Sensitive
:
C3
BAY 1895344
Sensitive: C3 – Early Trials
BAY 1895344
Sensitive
:
C3
ATM mutation
Gastroesophageal Junction Adenocarcinoma
ATM mutation
Gastroesophageal Junction Adenocarcinoma
Immunotherapy
Sensitive: C3 – Early Trials
Immunotherapy
Sensitive
:
C3
Immunotherapy
Sensitive: C3 – Early Trials
Immunotherapy
Sensitive
:
C3
ATM mutation
Gastric Adenocarcinoma
ATM mutation
Gastric Adenocarcinoma
Immunotherapy
Sensitive: C3 – Early Trials
Immunotherapy
Sensitive
:
C3
Immunotherapy
Sensitive: C3 – Early Trials
Immunotherapy
Sensitive
:
C3
ATM mutation
Colon Cancer
ATM mutation
Colon Cancer
Immunotherapy
Sensitive: C3 – Early Trials
Immunotherapy
Sensitive
:
C3
Immunotherapy
Sensitive: C3 – Early Trials
Immunotherapy
Sensitive
:
C3
ATM mutation
Mantle Cell Lymphoma
ATM mutation
Mantle Cell Lymphoma
venetoclax + ibrutinib
Sensitive: C3 – Early Trials
venetoclax + ibrutinib
Sensitive
:
C3
venetoclax + ibrutinib
Sensitive: C3 – Early Trials
venetoclax + ibrutinib
Sensitive
:
C3
ATM mutation
Squamous Cell Carcinoma of Head and Neck
ATM mutation
Squamous Cell Carcinoma of Head and Neck
durvalumab
Sensitive: C3 – Early Trials
durvalumab
Sensitive
:
C3
durvalumab
Sensitive: C3 – Early Trials
durvalumab
Sensitive
:
C3
ATM mutation
Prostate Cancer
ATM mutation
Prostate Cancer
pembrolizumab
Sensitive: C3 – Early Trials
pembrolizumab
Sensitive
:
C3
pembrolizumab
Sensitive: C3 – Early Trials
pembrolizumab
Sensitive
:
C3
ATM mutation
Prostate Cancer
ATM mutation
Prostate Cancer
GnRH stimulant
Resistant: C3 – Early Trials
GnRH stimulant
Resistant
:
C3
GnRH stimulant
Resistant: C3 – Early Trials
GnRH stimulant
Resistant
:
C3
ATM mutation
Pancreatic Ductal Adenocarcinoma
ATM mutation
Pancreatic Ductal Adenocarcinoma
durvalumab + gemcitabine + tremelimumab
Sensitive: C3 – Early Trials
durvalumab + gemcitabine + tremelimumab
Sensitive
:
C3
durvalumab + gemcitabine + tremelimumab
Sensitive: C3 – Early Trials
durvalumab + gemcitabine + tremelimumab
Sensitive
:
C3
ATM mutation
Prostate Cancer
ATM mutation
Prostate Cancer
avelumab
Sensitive: C3 – Early Trials
avelumab
Sensitive
:
C3
avelumab
Sensitive: C3 – Early Trials
avelumab
Sensitive
:
C3
ATM mutation
Ovarian Cancer
ATM mutation
Ovarian Cancer
olaparib + AZD6738
Sensitive: C3 – Early Trials
olaparib + AZD6738
Sensitive
:
C3
olaparib + AZD6738
Sensitive: C3 – Early Trials
olaparib + AZD6738
Sensitive
:
C3
ATM mutation
Non Small Cell Lung Cancer
ATM mutation
Non Small Cell Lung Cancer
Immunotherapy
Sensitive: C3 – Early Trials
Immunotherapy
Sensitive
:
C3
Immunotherapy
Sensitive: C3 – Early Trials
Immunotherapy
Sensitive
:
C3
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