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Association details:
Biomarker:ATM deletion
Cancer:Solid Tumor
Drug:elimusertib (BAY 1895344) (ATR inhibitor)
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: C2 – Inclusion Criteria
Title:

First-in-human Study of ATR Inhibitor BAY1895344 in Patients With Advanced Solid Tumors and Lymphomas

Excerpt:
...Patients with tumors known to be positive for deoxyribonucleic acid damage repair (DDR) defects (such as ataxia-telangiectasia mutated [ATM] deleterious mutation or low ATM expression) can be included....
Trial ID:
Evidence Level:
Sensitive: C3 – Early Trials
Title:

ATR Inhibition as an Attractive Therapeutic Resource against Cancer

Excerpt:
...BAY 1895344, a new potent and specific ATR inhibitor, is safe and able to induce durable responses in ATM-deficient tumors.
DOI:
10.1158/2159-8290.CD-20-1354