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DRUG:

ASN007

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Company:

Asana BioSci, Erasca, UT MD Anderson Cancer Center

Drug class:

ERK2 inhibitor, ERK1 inhibitor

Related drugs:

KRAS mutation	Colorectal Cancer	KRAS mutation	Colorectal Cancer	ASN007 Sensitive: C2 – Inclusion Criteria ASN007 Sensitive : C2	ASN007 Sensitive: C2 – Inclusion Criteria ASN007 Sensitive : C2
BRAF V600E	Colorectal Cancer	BRAF V600E	Colorectal Cancer	ASN007 Sensitive: C2 – Inclusion Criteria ASN007 Sensitive : C2	ASN007 Sensitive: C2 – Inclusion Criteria ASN007 Sensitive : C2
KRAS mutation	Non Small Cell Lung Cancer	KRAS mutation	Non Small Cell Lung Cancer	ASN007 + ERAS-601 Sensitive: C2 – Inclusion Criteria ASN007 + ERAS-601 Sensitive : C2	ASN007 + ERAS-601 Sensitive: C2 – Inclusion Criteria ASN007 + ERAS-601 Sensitive : C2
NRAS G13D	Mantle Cell Lymphoma	NRAS G13D	Mantle Cell Lymphoma	ASN007 Sensitive: D – Preclinical ASN007 Sensitive : D	ASN007 Sensitive: D – Preclinical ASN007 Sensitive : D
KRAS G13D	Pancreatic Adenocarcinoma	KRAS G13D	Pancreatic Adenocarcinoma	ASN007 Sensitive: D – Preclinical ASN007 Sensitive : D	ASN007 Sensitive: D – Preclinical ASN007 Sensitive : D
KRAS G12C	Pancreatic Adenocarcinoma	KRAS G12C	Pancreatic Adenocarcinoma	ASN007 Sensitive: D – Preclinical ASN007 Sensitive : D	ASN007 Sensitive: D – Preclinical ASN007 Sensitive : D
NRAS Q61K	Neuroblastoma	NRAS Q61K	Neuroblastoma	ASN007 Sensitive: D – Preclinical ASN007 Sensitive : D	ASN007 Sensitive: D – Preclinical ASN007 Sensitive : D
KRAS G13D	Colorectal Adenocarcinoma	KRAS G13D	Colorectal Adenocarcinoma	ASN007 Sensitive: D – Preclinical ASN007 Sensitive : D	ASN007 Sensitive: D – Preclinical ASN007 Sensitive : D
BRAF V600E	Melanoma	BRAF V600E	Melanoma	ASN007 Sensitive: D – Preclinical ASN007 Sensitive : D	ASN007 Sensitive: D – Preclinical ASN007 Sensitive : D
KRAS mutation	Colorectal Cancer	KRAS mutation	Colorectal Cancer	palbociclib + ASN007 Sensitive: D – Preclinical palbociclib + ASN007 Sensitive : D	palbociclib + ASN007 Sensitive: D – Preclinical palbociclib + ASN007 Sensitive : D
BRAF V600E	Colorectal Cancer	BRAF V600E	Colorectal Cancer	cetuximab + encorafenib + ASN007 Sensitive: D – Preclinical cetuximab + encorafenib + ASN007 Sensitive : D	cetuximab + encorafenib + ASN007 Sensitive: D – Preclinical cetuximab + encorafenib + ASN007 Sensitive : D
KRAS mutation	Pancreatic Ductal Adenocarcinoma	KRAS mutation	Pancreatic Ductal Adenocarcinoma	ASN007 + ERAS-601 Sensitive: D – Preclinical ASN007 + ERAS-601 Sensitive : D	ASN007 + ERAS-601 Sensitive: D – Preclinical ASN007 + ERAS-601 Sensitive : D
KRAS mutation	Colorectal Cancer	KRAS mutation	Colorectal Cancer	ASN007 + ERAS-601 Sensitive: D – Preclinical ASN007 + ERAS-601 Sensitive : D	ASN007 + ERAS-601 Sensitive: D – Preclinical ASN007 + ERAS-601 Sensitive : D