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Association details:
| Biomarker: | ARID1A deletion |
|---|---|
| Cancer: | Gastric Cancer |
| Drug: | SC0245 (ATR inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Preclinical evaluation of SC0245, a small molecule inhibitor of ATR kinase.
Published date:
05/28/2020
Excerpt:
...SC0245 significantly inhibited cell proliferation in ATM pathway or ARID1A deficient LoVo cells with IC50 0.163 μM, SNU-601 cells with IC50 0.218 μM....Moreover, in the SNU601 and LoVo CDX mouse models, SC0245 oral administration significantly inhibited tumor growth...SC0245 represents a promising clinical candidate for treating solid cancers, such as gastric and colorectal cancers.
DOI:
10.1200/JCO.2020.38.15_suppl.e15642
