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Association details:
Biomarker:ARID1A deletion
Cancer:Gastric Cancer
Drug:SC0245 (ATR inhibitor)
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Source:
Title:

Preclinical evaluation of SC0245, a small molecule inhibitor of ATR kinase.

Published date:
05/28/2020
Excerpt:
...SC0245 significantly inhibited cell proliferation in ATM pathway or ARID1A deficient LoVo cells with IC50 0.163 μM, SNU-601 cells with IC50 0.218 μM....Moreover, in the SNU601 and LoVo CDX mouse models, SC0245 oral administration significantly inhibited tumor growth...SC0245 represents a promising clinical candidate for treating solid cancers, such as gastric and colorectal cancers.
DOI:
10.1200/JCO.2020.38.15_suppl.e15642