^
Association details:
Biomarker:ARID1A 548fs
Cancer:Ovarian Cancer
Drug:VE-821 (ATR inhibitor)
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: D – Preclinical
New
Source:
Title:

ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A

Excerpt:
We also determined the in vivo efficacy of VX-970 in mice with established tumours derived from a tumour cell line with naturally occurring ARID1A mutations (TOV21G, ARID1A p.548fs/p.756fs). In in vitro studies, we found that the TOV21G human OCCC cell line was more sensitive to both VE-821 and VX-970 than the ARID1A wild-type OCCC cell line RMG1
DOI:
10.1038/ncomms13837