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Association details:
Biomarker:
AR positive
Cancer:
Prostate Cancer
Drug:
Xtandi (enzalutamide capsule)
(
Androgen receptor inhibitor
) +
zoligratinib (Debio 1347)
(
FGFR inhibitor
)
Direction:
Sensitive
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Source:
Prostate
Title:
Targeting the fibroblast growth factor pathway in molecular subtypes of castration-resistant prostate cancer
Published date:
10/05/2023
Excerpt:
In vivo studies using four ARPC PDX models showed that combination ENZA and CH5183284 significantly suppressed tumor growth.
DOI:
10.1002/pros.24630
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