^
Association details:
| Biomarker: | AR expression |
|---|---|
| Cancer: | Prostate Cancer |
| Drug: | SID 3712502 (Androgen receptor inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Inhibition of Androgen Receptor Function and Level in Castration-Resistant Prostate Cancer Cells by 2-[(isoxazol-4-ylmethyl)thio]-1-(4-phenylpiperazin-1-yl)ethanone
Excerpt:
In this study, we show that IMTPPE inhibits AR-target gene expression using real-time polymerase chain reaction...IMTPPE is a potential lead compound for developing clinical candidates for the treatment of CRPC, including those resistant to enzalutamide.
DOI:
10.1210/en.2017-00408
