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Association details:
Biomarker:AR expression
Cancer:Prostate Cancer
Drug:SID 3712502 (Androgen receptor inhibitor)
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: D – Preclinical
New
Title:

Inhibition of Androgen Receptor Function and Level in Castration-Resistant Prostate Cancer Cells by 2-[(isoxazol-4-ylmethyl)thio]-1-(4-phenylpiperazin-1-yl)ethanone

Excerpt:
In this study, we show that IMTPPE inhibits AR-target gene expression using real-time polymerase chain reaction...IMTPPE is a potential lead compound for developing clinical candidates for the treatment of CRPC, including those resistant to enzalutamide.
DOI:
10.1210/en.2017-00408