^
Association details:
| Biomarker: | APC mutation |
|---|---|
| Cancer: | Colorectal Cancer |
| Drug: | G007-LK (TNKS inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth
Excerpt:
Compound G007-LK displays favorable pharmacokinetic properties and inhibits in vivo tumor growth in a subset of APC-mutant CRC xenograft models.
DOI:
10.1158/0008-5472.CAN-12-4562
