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Association details:
| Biomarker: | ALK R1275Q |
|---|---|
| Cancer: | Neuroblastoma |
| Drug: | TAE-684 (ALK inhibitor, LRRK2 inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Activating mutations in ALK provide a therapeutic target in neuroblastoma
Excerpt:
...SMS-KCNR cell line expressing the ALK R1275Q mutation was resistant to TAE684 (IC50 of 4.9 µM; Fig. 2a)...ALK was expressed at substantially lower levels in the TAE684-sensitive neuroblastoma cell lines [Kelly (F1174L), and SH-SY5Y (F1174L)] than in the remaining cell lines harboring either wild-type ALK or the R1275Q mutation...
DOI:
10.1038/nature07397
