^
Association details:
| Biomarker: | AKT1 overexpression |
|---|---|
| Cancer: | Glioblastoma |
| Drug: | Kominox (sodium metaarsenite) (NF-κB inhibitor, Telomerase inhibitor, VEGF-C inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Anti-Tumor Effects of Sodium Meta-Arsenite in Glioblastoma Cells with Higher Akt Activities
Published date:
11/26/2020
Excerpt:
...we evaluated the effect of sodium meta-arsenite, KML001, on the growth of human glioblastoma cell lines with different PTEN expression status and Akt activation, including PTEN-deficient cells (U87-MG and U251) and PTEN-positive cells (LN229)...KML001 inhibited cell growth more effectively in active Akt-overexpressing LN229 cells than in mock-expressing LN229 cells.
DOI:
10.3390/ijms21238982
