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Association details:
| Biomarker: | ADAM9 positive |
|---|---|
| Cancer: | Solid Tumor |
| Drug: | izeltabart tapatansine (IMGC936) (Microtubule inhibitor, ADAM9-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Preclinical Evaluation of IMGC936, a Next-Generation Maytansinoid-based Antibody-drug Conjugate Targeting ADAM9-expressing Tumors
Published date:
07/05/2022
Excerpt:
IMGC936 exhibited cytotoxicity toward ADAM9-positive human tumor cell lines, as well as bystander killing, potent antitumor activity in human cell line-derived xenograft and patient-derived xenograft tumor models...
DOI:
10.1158/1535-7163.MCT-21-0915
