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DRUG:
Krazati (adagrasib)
i
Other names:
MRTX849, MRTX 849 , MRTX-849
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Associations
(35)
News
Trials
Company:
BMS, ZAI Lab
Drug class:
KRAS G12C inhibitor
Related drugs:
‹
sotorasib (76)
RG6330 (6)
D-1553 (6)
fulzerasib (4)
ZG19018 (4)
JAB-21822 (4)
APG-1842 (3)
ARS-1620 (2)
BI 1823911 (2)
MK-1084 (2)
JDQ443 (2)
ABSK071 (1)
AZ’8037 (1)
GEC-255 (1)
RM-029 (1)
YL-17231 (1)
D3S-001 (0)
FWD-K01 (0)
GH35 (0)
HBI-2438 (0)
HS-10370 (0)
JNJ-74699157 (0)
LY3499446 (0)
RMC-6291 (0)
UCT-001024 (0)
VRTX126 (0)
YL-15293 (0)
LY3537982 (0)
sotorasib (76)
RG6330 (6)
D-1553 (6)
fulzerasib (4)
ZG19018 (4)
JAB-21822 (4)
APG-1842 (3)
ARS-1620 (2)
BI 1823911 (2)
MK-1084 (2)
JDQ443 (2)
ABSK071 (1)
AZ’8037 (1)
GEC-255 (1)
RM-029 (1)
YL-17231 (1)
D3S-001 (0)
FWD-K01 (0)
GH35 (0)
HBI-2438 (0)
HS-10370 (0)
JNJ-74699157 (0)
LY3499446 (0)
RMC-6291 (0)
UCT-001024 (0)
VRTX126 (0)
YL-15293 (0)
LY3537982 (0)
›
Associations
(35)
News
Trials
VERI cancer hierarchy
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KRAS G12C
Non Small Cell Lung Cancer
KRAS G12C
Non Small Cell Lung Cancer
adagrasib
Sensitive: A1 - Approval
adagrasib
Sensitive
:
A1
adagrasib
Sensitive: A1 - Approval
adagrasib
Sensitive
:
A1
KRAS G12C
Colorectal Cancer
KRAS G12C
Colorectal Cancer
adagrasib
Sensitive: A1 - Approval
adagrasib
Sensitive
:
A1
adagrasib
Sensitive: A1 - Approval
adagrasib
Sensitive
:
A1
KRAS G12C
Colorectal Cancer
KRAS G12C
Colorectal Cancer
cetuximab + adagrasib
Sensitive: A1 - Approval
cetuximab + adagrasib
Sensitive
:
A1
cetuximab + adagrasib
Sensitive: A1 - Approval
cetuximab + adagrasib
Sensitive
:
A1
KRAS G12C
Pancreatic Adenocarcinoma
KRAS G12C
Pancreatic Adenocarcinoma
adagrasib
Sensitive: A2 - Guideline
adagrasib
Sensitive
:
A2
adagrasib
Sensitive: A2 - Guideline
adagrasib
Sensitive
:
A2
KRAS G12C
Rectal Cancer
KRAS G12C
Rectal Cancer
panitumumab + adagrasib
Sensitive: A2 - Guideline
panitumumab + adagrasib
Sensitive
:
A2
panitumumab + adagrasib
Sensitive: A2 - Guideline
panitumumab + adagrasib
Sensitive
:
A2
KRAS G12C
Rectal Cancer
KRAS G12C
Rectal Cancer
cetuximab + adagrasib
Sensitive: A2 - Guideline
cetuximab + adagrasib
Sensitive
:
A2
cetuximab + adagrasib
Sensitive: A2 - Guideline
cetuximab + adagrasib
Sensitive
:
A2
KRAS G12C
Colon Cancer
KRAS G12C
Colon Cancer
cetuximab + adagrasib
Sensitive: A2 - Guideline
cetuximab + adagrasib
Sensitive
:
A2
cetuximab + adagrasib
Sensitive: A2 - Guideline
cetuximab + adagrasib
Sensitive
:
A2
KRAS G12C
Colon Cancer
KRAS G12C
Colon Cancer
panitumumab + adagrasib
Sensitive: A2 - Guideline
panitumumab + adagrasib
Sensitive
:
A2
panitumumab + adagrasib
Sensitive: A2 - Guideline
panitumumab + adagrasib
Sensitive
:
A2
KRAS G12C
Ampulla of Vater Carcinoma
KRAS G12C
Ampulla of Vater Carcinoma
adagrasib
Sensitive: A2 - Guideline
adagrasib
Sensitive
:
A2
adagrasib
Sensitive: A2 - Guideline
adagrasib
Sensitive
:
A2
KRAS G12C
Cholangiocarcinoma
KRAS G12C
Cholangiocarcinoma
adagrasib
Sensitive: C1 - Off-label
adagrasib
Sensitive
:
C1
adagrasib
Sensitive: C1 - Off-label
adagrasib
Sensitive
:
C1
KRAS G12C
Ovarian Cancer
KRAS G12C
Ovarian Cancer
adagrasib
Sensitive: C1 - Off-label
adagrasib
Sensitive
:
C1
adagrasib
Sensitive: C1 - Off-label
adagrasib
Sensitive
:
C1
KRAS G12C
Pancreatic Cancer
KRAS G12C
Pancreatic Cancer
adagrasib
Sensitive: C1 - Off-label
adagrasib
Sensitive
:
C1
adagrasib
Sensitive: C1 - Off-label
adagrasib
Sensitive
:
C1
KRAS G12C
Endometrial Cancer
KRAS G12C
Endometrial Cancer
adagrasib
Sensitive: C1 - Off-label
adagrasib
Sensitive
:
C1
adagrasib
Sensitive: C1 - Off-label
adagrasib
Sensitive
:
C1
KRAS G12C
Gastrointestinal Cancer
KRAS G12C
Gastrointestinal Cancer
adagrasib
Sensitive: C1 - Off-label
adagrasib
Sensitive
:
C1
adagrasib
Sensitive: C1 - Off-label
adagrasib
Sensitive
:
C1
KRAS G12C
Pancreatic Ductal Adenocarcinoma
KRAS G12C
Pancreatic Ductal Adenocarcinoma
adagrasib
Sensitive: C1 - Off-label
adagrasib
Sensitive
:
C1
adagrasib
Sensitive: C1 - Off-label
adagrasib
Sensitive
:
C1
KRAS G12C
Lung Cancer
KRAS G12C
Lung Cancer
adagrasib
Sensitive: C1 - Off-label
adagrasib
Sensitive
:
C1
adagrasib
Sensitive: C1 - Off-label
adagrasib
Sensitive
:
C1
KRAS G12C
Solid Tumor
KRAS G12C
Solid Tumor
adagrasib
Sensitive: C1 - Off-label
adagrasib
Sensitive
:
C1
adagrasib
Sensitive: C1 - Off-label
adagrasib
Sensitive
:
C1
KRAS G12C
Biliary Tract Cancer
KRAS G12C
Biliary Tract Cancer
adagrasib
Sensitive: C1 - Off-label
adagrasib
Sensitive
:
C1
adagrasib
Sensitive: C1 - Off-label
adagrasib
Sensitive
:
C1
KRAS G12C + STK11 mutation
Non Small Cell Lung Cancer
KRAS G12C + STK11 mutation
Non Small Cell Lung Cancer
adagrasib
Sensitive: C3 – Early Trials
adagrasib
Sensitive
:
C3
adagrasib
Sensitive: C3 – Early Trials
adagrasib
Sensitive
:
C3
KRAS G12C
Lung Adenocarcinoma
KRAS G12C
Lung Adenocarcinoma
adagrasib + TVB-3664
Sensitive: D – Preclinical
adagrasib + TVB-3664
Sensitive
:
D
adagrasib + TVB-3664
Sensitive: D – Preclinical
adagrasib + TVB-3664
Sensitive
:
D
KRAS G12C
Non Small Cell Lung Cancer
KRAS G12C
Non Small Cell Lung Cancer
sotorasib + adagrasib + VS-6766
Sensitive: D – Preclinical
sotorasib + adagrasib + VS-6766
Sensitive
:
D
sotorasib + adagrasib + VS-6766
Sensitive: D – Preclinical
sotorasib + adagrasib + VS-6766
Sensitive
:
D
KRAS G12C
Colorectal Cancer
KRAS G12C
Colorectal Cancer
sotorasib + adagrasib + VS-6766
Sensitive: D – Preclinical
sotorasib + adagrasib + VS-6766
Sensitive
:
D
sotorasib + adagrasib + VS-6766
Sensitive: D – Preclinical
sotorasib + adagrasib + VS-6766
Sensitive
:
D
KRAS G13D
Solid Tumor
KRAS G13D
Solid Tumor
adagrasib
Sensitive: D – Preclinical
adagrasib
Sensitive
:
D
adagrasib
Sensitive: D – Preclinical
adagrasib
Sensitive
:
D
KRAS Q99L
Solid Tumor
KRAS Q99L
Solid Tumor
adagrasib
Resistant: D – Preclinical
adagrasib
Resistant
:
D
adagrasib
Resistant: D – Preclinical
adagrasib
Resistant
:
D
KRAS A59T
Solid Tumor
KRAS A59T
Solid Tumor
adagrasib
Sensitive: D – Preclinical
adagrasib
Sensitive
:
D
adagrasib
Sensitive: D – Preclinical
adagrasib
Sensitive
:
D
KRAS A59S
Solid Tumor
KRAS A59S
Solid Tumor
adagrasib
Sensitive: D – Preclinical
adagrasib
Sensitive
:
D
adagrasib
Sensitive: D – Preclinical
adagrasib
Sensitive
:
D
KRAS R68M
Solid Tumor
KRAS R68M
Solid Tumor
adagrasib
Sensitive: D – Preclinical
adagrasib
Sensitive
:
D
adagrasib
Sensitive: D – Preclinical
adagrasib
Sensitive
:
D
KRAS Y96S
Solid Tumor
KRAS Y96S
Solid Tumor
adagrasib
Resistant: D – Preclinical
adagrasib
Resistant
:
D
adagrasib
Resistant: D – Preclinical
adagrasib
Resistant
:
D
KRAS Y96D
Solid Tumor
KRAS Y96D
Solid Tumor
adagrasib
Resistant: D – Preclinical
adagrasib
Resistant
:
D
adagrasib
Resistant: D – Preclinical
adagrasib
Resistant
:
D
KRAS G12C
Lung Cancer
KRAS G12C
Lung Cancer
adagrasib + ENV-201
Sensitive: D – Preclinical
adagrasib + ENV-201
Sensitive
:
D
adagrasib + ENV-201
Sensitive: D – Preclinical
adagrasib + ENV-201
Sensitive
:
D
KRAS G12C
Bladder Cancer
KRAS G12C
Bladder Cancer
adagrasib + nanoparticle albumin-bound rapamycin
Sensitive: D – Preclinical
adagrasib + nanoparticle albumin-bound rapamycin
Sensitive
:
D
adagrasib + nanoparticle albumin-bound rapamycin
Sensitive: D – Preclinical
adagrasib + nanoparticle albumin-bound rapamycin
Sensitive
:
D
KRAS G12C
Non Small Cell Lung Cancer
KRAS G12C
Non Small Cell Lung Cancer
adagrasib + nanoparticle albumin-bound rapamycin
Sensitive: D – Preclinical
adagrasib + nanoparticle albumin-bound rapamycin
Sensitive
:
D
adagrasib + nanoparticle albumin-bound rapamycin
Sensitive: D – Preclinical
adagrasib + nanoparticle albumin-bound rapamycin
Sensitive
:
D
^
^
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