^
Association details:
| Biomarker: | ABCG2 overexpression |
|---|---|
| Cancer: | Colorectal Cancer |
| Drug: | GSK2606414 (RIPK1 inhibitor, PERK inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
GSK2606414 Sensitizes ABCG2-Overexpressing Multidrug-Resistant Colorectal Cancer Cells to Chemotherapeutic Drugs
Published date:
11/20/2023
Excerpt:
We found that the compound GSK2606414 enhanced the sensitivity of the ABCG2 substrate to the chemotherapeutic drugs mitoxantrone and doxorubicin in ABCG2-overexpressing multidrug-resistant colorectal cancer cells...In conclusion, GSK2606414 can sensitize ABCG2-overexpressed multidrug-resistant colorectal cancer cells to chemotherapy drugs and can be used as a potential inhibitor of ABCG2.
DOI:
https://doi.org/10.3390/biomedicines11113103
