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Association details:
| Biomarker: | ABCB1 overexpression |
|---|---|
| Cancer: | Ovarian Cancer |
| Drug: | lapatinib (EGFR inhibitor, HER2 inhibitor) + Pozenveo (poziotinib) (HER2 inhibitor, HER4 inhibitor, pan-EGFR inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Lapatinib and poziotinib overcome ABCB1-mediated paclitaxel resistance in ovarian cancer
Published date:
08/04/2021
Excerpt:
...lapatinib and poziotinib combined with paclitaxel synergizes to inhibit the proliferation of ABCB1-overexpressing ovarian cancer cells in vitro.
DOI:
10.1371/journal.pone.0254205