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    Association details:
    Biomarker:ABCB1 overexpression
    Cancer:Non Small Cell Lung Cancer
    Drug:paclitaxel (Bcl2 inhibitor, Tubulin polymerization promoter)
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: D – Preclinical
    New
    Source:
    Mol Ther Nucleic Acids
    Title:

    CS-PEI/Beclin-siRNA Downregulate Multidrug Resistance Proteins and Increase Paclitaxel Therapeutic Efficacy against NSCLC

    Excerpt:
    Compared with NCI-H23, NCI-H23-TXR had higher expression levels in P-glycoprotein (P-gp) and multidrug resistance protein 7 (ABCC10).
    DOI:
    10.1016/j.omtn.2019.06.017