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Association details:
| Biomarker: | ABCB1 overexpression |
|---|---|
| Cancer: | Multiple Myeloma |
| Drug: | carfilzomib (Proteasome inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Predicting Carfilzomib Resistance Mechanisms and Therapeutics Using Computational Modelling of Genomics and Proteomics
Published date:
11/01/2018
Excerpt:
The objective of the study was to predict response to proteasome inhibitor Carfilzomib (CFZ) in AMO1 MM disease model...Carfilzomib drug exporter ABCB1 was overexpressed in CFZ-resistant cells…
