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DRUG CLASS:
VEGFR inhibitor
DRUG CLASS:
VEGFR inhibitor
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News alerts, weekly reports and conference planners
Related drugs:
‹
sunitinib (139)
lenvatinib (90)
axitinib (34)
fruquintinib (24)
cediranib (9)
TKI258 (9)
surufatinib (7)
MGCD265 (4)
E 3810 (4)
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vorolanib (1)
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adAptVEGF-C adenoviral vector (0)
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SYHA1813 (0)
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ABT-165 (0)
IMC-18F1 (0)
ABT348 (0)
PI-88 (0)
SU5416 (0)
GS 6624 (0)
BAY 57- 9352 (0)
RG7221 (0)
PTK787 (0)
sunitinib (139)
lenvatinib (90)
axitinib (34)
fruquintinib (24)
cediranib (9)
TKI258 (9)
surufatinib (7)
MGCD265 (4)
E 3810 (4)
OMP-305B83 (3)
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DC101 (1)
vorolanib (1)
CS 2164 (1)
KD019 (1)
BMS690514 (0)
CVX-241 (0)
ESK981 (0)
adAptVEGF-C adenoviral vector (0)
SU 14813 (0)
SYHA1813 (0)
VEGFR1-1084 (0)
ABT-165 (0)
IMC-18F1 (0)
ABT348 (0)
PI-88 (0)
SU5416 (0)
GS 6624 (0)
BAY 57- 9352 (0)
RG7221 (0)
PTK787 (0)
›
Associations
(336)
News
Trials
Search handles
@AaronGoodman33
@AlbigesL
@AndresFCardonaZ
@ArndtVogel
@AtishChoudhury
@AzadOncology
@CathyEngMD
@CharuAggarwalMD
@ChungHanLee3
@DrChoueiri
@DrCraigGedye
@DrDanielHeng
@DrHKantarjian
@Dr_R_Kurzrock
@ERPlimackMD
@GABOUALFA
@GlopesMd
@HH_Oncodr
@HHammersMD
@Jbauml
@LeciaSequist
@MPishvaian
@MosheOrnsteinMD
@Myeloma_Doc
@OncoLucus
@PauloBergerot
@RenoHemonc
@RonenStoff
@ShannonWestin
@StephenVLiu
@TalhaBadarMD
@TapKadia
@TiansterZhang
@VivekSubbiah
@aparna1024
@bilenma
@bpiperdi
@brian_rini
@cczielinski
@dhjutsw1
@doctorpemm
@dr_yakupergun
@jasonlukemd
@jayastuMD
@jgong15
@jsoriamd
@marklewismd
@montypal
@nataliagandur
@neerajaiims
@ns_chd
@pashtoonkasi
@smbenlazar
@tnewsomdavis
@tompowles1
@yekeduz_emre
Search handles
@AaronGoodman33
@AlbigesL
@AndresFCardonaZ
@ArndtVogel
@AtishChoudhury
@AzadOncology
@CathyEngMD
@CharuAggarwalMD
@ChungHanLee3
@DrChoueiri
@DrCraigGedye
@DrDanielHeng
@DrHKantarjian
@Dr_R_Kurzrock
@ERPlimackMD
@GABOUALFA
@GlopesMd
@HH_Oncodr
@HHammersMD
@Jbauml
@LeciaSequist
@MPishvaian
@MosheOrnsteinMD
@Myeloma_Doc
@OncoLucus
@PauloBergerot
@RenoHemonc
@RonenStoff
@ShannonWestin
@StephenVLiu
@TalhaBadarMD
@TapKadia
@TiansterZhang
@VivekSubbiah
@aparna1024
@bilenma
@bpiperdi
@brian_rini
@cczielinski
@dhjutsw1
@doctorpemm
@dr_yakupergun
@jasonlukemd
@jayastuMD
@jgong15
@jsoriamd
@marklewismd
@montypal
@nataliagandur
@neerajaiims
@ns_chd
@pashtoonkasi
@smbenlazar
@tnewsomdavis
@tompowles1
@yekeduz_emre
Filter by
Latest
9ms
Check out the final version of the @UChicagoLeuk article on FLT3 inhibitors in pts with FLT3 N676K mutated AML! The effort was led by @RoloffGreg @michaelwd https://t.co/VLDjMBnnfH (@UChicagoLeuk)
9 months ago
Clinical
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FLT3 (Fms-related tyrosine kinase 3)
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FLT3 N676K
9ms
Lenvatinib plus pembrolizumab demonstrated improved ORR compared with sunitinib monotherapy in treatment-naïve patients with advanced RCC regardless of risk status or PD-L1 expression. @motzermd @MSKCancerCenter @kidneycan #KCRS23 #kcsm https://t.co/p1LcSl5Czk (@OncLive)
9 months ago
Clinical • IO biomarker • Metastases
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PD-L1 (Programmed death ligand 1)
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PD-L1 expression
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Keytruda (pembrolizumab) • Sutent (sunitinib) • Lenvima (lenvatinib)
9ms
Sequential therapies after atezolizumab plus bevacizumab or lenvatinib first-line treatments in HCC @OncologyAdvance https://t.co/xit1v39BjF ❓What should we do and what can we expect for 2nd line therapy 🌍RWD suggest: 👉AtzeBev > Lenva 👉Lenva > ICI @myESMO @ILCAnews @EASLedu… https://t.co/ALX315Novm (@ArndtVogel)
9 months ago
Clinical
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Avastin (bevacizumab) • Tecentriq (atezolizumab) • Lenvima (lenvatinib)
9ms
Comparing the cost-effectiveness of immunotherapy-based regimens and sunitinib in treating metastatic #RenalCellCarcinoma from a public payer perspective. Manish Kohli, MD @huntsmancancer joins @PBarataMD @caseccc to discuss on UroToday > https://t.co/pKTfVnZcwj @JCOOP_ASCO (@urotoday)
9 months ago
Clinical • HEOR • Cost effectiveness • Metastases
|
Sutent (sunitinib)
9ms
According to data from the final OS analysis of the CLEAR study, lenvatinib plus pembrolizumab produced an ORR of 71.3% in treatment-naïve patients with advanced RCC vs 36.7% with sunitinib. @motzermd @MSKCancerCenter @kidneycan #KCRS23 #kcsm https://t.co/NDvc1gD1Ne (@OncLive)
9 months ago
Clinical • Metastases
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Keytruda (pembrolizumab) • Sutent (sunitinib) • Lenvima (lenvatinib)
9ms
11/16 #TumorBoardTuesday #RCC Back to our case 🔎 👨🏼🦳 Patient starts cabozantinib at 60mg qd 📆 3 mos ✋🏽🦶🏽G3 ⬇️dose reduce to 40mg 🩻scans: PR lasts for one year 🫁single new pulm met 🧐What treatment option do you consider next after progression of pembro/axi and cabo? (@katy_beckermann)
9 months ago
Clinical
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Keytruda (pembrolizumab) • Cabometyx (cabozantinib tablet) • Inlyta (axitinib)
9ms
15a/16 #TumorBoardTuesday 🧑🏼🔬Ongoing Trials assessing belzutifan in sporadic met #RCC ✨Pembro+lenva: https://t.co/RseK3omjaO ✨Belzu+pembro v placebo+pembro: https://t.co/UIZCuOHgoR ✨Pembro+belzu+lenva OR pembro/Quavo+lenva v pembro+lenva https://t.co/QTUdhDsyb9 (@katy_beckermann)
9 months ago
Clinical
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Keytruda (pembrolizumab) • Lenvima (lenvatinib) • Welireg (belzutifan)
9ms
13/16 #TumorBoardTuesday Back to case🔎 64yo👨🏼🦳 met #RCC to 🫁 & adrenal 💊pembro/axitinib 📆18 mos PD to liver 🩻PR on cabo: single growing met 💊Cabo & SBRT 🙌🏽 SD for 6 mos 🩻scans: growth in liver & 🫁 🧐What tx do you consider next after progression of pembro/axi and cabo? (@katy_beckermann)
9 months ago
Keytruda (pembrolizumab) • Inlyta (axitinib)
9ms
🗞️ Published in @TheLancetOncol and co-authored by VHIO’s @crisuarez08, results from the single-arm phase II KEYNOTE-B61 clinical trial support the use of pembrolizumab plus lenvatinib in patients with previously untreated advanced non-clear cell renal cell carcinoma. ➕… https://t.co/qUn891LZBA (@VHIO)
9 months ago
Clinical • Metastases
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Keytruda (pembrolizumab) • Lenvima (lenvatinib)
10ms
Lenvatinib/Pembrolizumab Benefit Is Upheld in Advanced RCC, Including ICI-Pretreated and Naïve Subgroups @ChungHanLee3 @MSKCancerCenter @kidneycan #KCRS23 #kcsm https://t.co/yU9CWV30fx (@OncLive)
10 months ago
Metastases
|
Keytruda (pembrolizumab) • Lenvima (lenvatinib)
10ms
Frontline Lenvatinib Plus Pembrolizumab Produces Superior Responses Vs Sunitinib in Advanced RCC @motzermd @MSKCancerCenter @kidneycan #KCRS23 #kcsm https://t.co/RQML5zNQnC (@OncLive)
10 months ago
Metastases
|
Keytruda (pembrolizumab) • Sutent (sunitinib) • Lenvima (lenvatinib)
10ms
The sustained OS benefit observed with pembrolizumab and lenvatinib in the CLEAR study solidifies the doublet’s use as a preferred option for the frontline treatment of patients with advanced RCC. @DrTHut @TexasOncology @SarahCannonDocs #kcsm https://t.co/Jmjj0bMNuC (@OncLive)
10 months ago
Clinical • Metastases
|
Keytruda (pembrolizumab) • Lenvima (lenvatinib)
10ms
Guess who stopped by? @ChungHanLee3, of @MSKCancerCenter! Thanks for speaking with us about the final results of the phase 2 cohort of lenvatinib + pembrolizumab for progressive disease after a PD-1/PD-L1-containing therapy in metastatic clear cell RCC #kcsm @kidneycan (@OncLive)
10 months ago
Clinical • P2 data • Metastases
|
Keytruda (pembrolizumab) • Lenvima (lenvatinib)
10ms
We spoke with @ChungHanLee3 from @MSKCancerCenter on the use of lenvatinib and pembrolizumab in patients with RCC. #kicsm | @kidneycan (@CancerNetwrk)
10 months ago
Clinical
|
Keytruda (pembrolizumab) • Lenvima (lenvatinib)
10ms
@DrChoueiri discussing SAMETA - p3 trial for savolitinib+durva vs sunitinib vs durva in pts with MET-driven papillary RCC @kidneycan #KCRS23 (@MosheOrnsteinMD)
10 months ago
Clinical
|
Sutent (sunitinib) • Orpathys (savolitinib)
10ms
S3: Trials In Progress ⚡️ SAMETA A Phase 3 Study of Savolitinib + Durva vs Sunitinib vs Durva Alone in Patients with MET-Driven Advanced Papillary RCC @DrChoueiri @DanaFarber_GU @kidneycan #KCRS23 (@MikeSerzanMD)
10 months ago
Clinical • P3 data • Metastases
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Sutent (sunitinib) • Orpathys (savolitinib)
10ms
Encouraging results in non-clear cell RCC. However, efficacy appears to be lower in the chromophobe subtype and in the PDL1-negative group. In the chromophobe type, lenvatinib + everolimus may be more effective. (@dr_yakupergun)
10 months ago
Clinical
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PD-L1 (Programmed death ligand 1)
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PD-L1 negative
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everolimus • Lenvima (lenvatinib)
10ms
⭐️KEYNOTE-B61 single-arm, ph 2 trial of first-line pembrolizumab plus lenvatinib for advanced non-clear-cell renal cell carcinoma, 78 of 158 patients had a confirmed objective response (49%; 95% CI 41–57) @TheLancetOncol @OncoAlert @AlbigesL https://t.co/59ZG4tZHVI (@VivekSubbiah)
10 months ago
Clinical • Metastases
|
Keytruda (pembrolizumab) • Lenvima (lenvatinib)
10ms
After a great presentation at @ASCO #ASCO23, full paper just out @TheLancetOncol Keynote B61: 🚹Non-clear cell mRCC 💊Pembrolizumab+Lenvatinib 1st line 🎯ORR:49%, CR:6% @DrChoueiri @AlbigesL @ChungHanLee3 @OncoAlert @DrYukselUrun https://t.co/pHrrelHSLb (@yekeduz_emre)
10 months ago
Keytruda (pembrolizumab) • Lenvima (lenvatinib)
10ms
Pleased to share @TheLancetOncol LENVA-PEMBRO across RCC variant histologies: papillary RCC, unclRCC and chromophobe RCC … interim @myESMO #ESMO22 and final @ChungHanLee3 @ASCO #ASCO23 full text: https://t.co/QioxQEiKho Thanks to all who change rareRCC pts Tx! (@AlbigesL)
10 months ago
Clinical
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Keytruda (pembrolizumab) • Lenvima (lenvatinib)
10ms
Nice tweet & pic capture, Dr Jay @jayastuMD ! I love this slide - thx 🙏🏾 for sharing 😃! #leusm #FLT3 | The citation ▶️ Pemmaraju et al is from a paper I wrote with Prof @GCC_Cortes in 2011 on review of FLT3 inhibitors - that’s right - over 12 y ago!! https://t.co/e4A1G5xCqo (@doctorpemm)
10 months ago
Review
10ms
The combination of pembrolizumab + axitinib continued to improve OS, PFS, & ORR over sunitinib monotherapy in patients with treatment-naïve clear cell RCC. @brian_rini @VUMChealth #kcsm https://t.co/tKcszvDygl (@OncLive)
10 months ago
Clinical
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Keytruda (pembrolizumab) • Sutent (sunitinib) • Inlyta (axitinib)
10ms
➡️ Focus group meeting on FLT3 inhibitors 💊 in AML by @DrHKantarjian @Daver_Leukemia @jaltmanmd and @ alexander perl @_MDEducation (@jayastuMD)
10 months ago
10ms
Long-Term OS Data Confirm Pembrolizumab/Lenvatinib as a Primary Frontline Option in Advanced RCC @DrTHut @TexasOncology @SarahCannonDocs #kcsm https://t.co/4CP5RKH4Vq (@OncLive)
10 months ago
Metastases
|
Keytruda (pembrolizumab) • Lenvima (lenvatinib)
10ms
Lenvatinib plus pembrolizumab showed a sustained overall survival and progression-free survival benefit vs sunitinib alone at a median follow-up of 4 years in patients with advanced renal cell carcinoma. @DrTHut @bswhealth https://t.co/2uj87xQ7pv (@OncLive)
10 months ago
Clinical • Metastases
|
Keytruda (pembrolizumab) • Sutent (sunitinib) • Lenvima (lenvatinib)
10ms
📹 Who are the optimal patients to receive pembrolizumab plus axitinib? Watch this interview with Dr. @brian_rini . He shares details with us on the 5-year analysis of the KEYNOTE-426 trial in advanced renal-cell carcinoma. 👇 https://t.co/5T4MMVK9BS #kidneycancer #oncology (@EAU_Uroonco)
10 months ago
Clinical • Interview • Metastases
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Keytruda (pembrolizumab) • Inlyta (axitinib)
10ms
Lenvatinib plus pembrolizumab showed a sustained overall survival and progression-free survival benefit vs sunitinib alone at a median follow-up of 4 years in patients with advanced renal cell carcinoma. @DrTHut @bswhealth https://t.co/PJMI5i2fqE (@OncLive)
10 months ago
Clinical • Metastases
|
Keytruda (pembrolizumab) • Sutent (sunitinib) • Lenvima (lenvatinib)
10ms
The combination of pembrolizumab + axitinib continued to improve OS, PFS, & ORR over sunitinib monotherapy in patients with treatment-naïve clear cell RCC. @brian_rini @VUMChealth #kcsm https://t.co/YN4Oz9QJRP (@OncLive)
10 months ago
Clinical
|
Keytruda (pembrolizumab) • Sutent (sunitinib) • Inlyta (axitinib)
10ms
Lenvatinib Plus Pembrolizumab vs Regorafenib or TAS for Previously Treated mCRC: Phase 3 LEAP-017 Study at #WCGIC2023 👉mOS: 9.8 vs 9.3 mo 👉There is some activity, but⛔️ 👉IO in MSS CRC remains a challenge... @WCGIC @myESMO @OncoAlert (@ArndtVogel)
10 months ago
P3 data
|
Keytruda (pembrolizumab) • Lenvima (lenvatinib) • Stivarga (regorafenib)
10ms
.@DrChoueiri and Rohit Gosain, MD, reviewed results from the phase 3 CheckMate 9ER trial which asseed nivolumab plus cabozantinib vs sunitinib in patients with renal cell carcinoma. #rccsm https://t.co/Sahrg8aNOy (@CancerNetwrk)
10 months ago
Clinical
|
Opdivo (nivolumab) • Sutent (sunitinib) • Cabometyx (cabozantinib tablet)
10ms
Thank you @CancerTherAdvsr for featuring our article on HRQOL outcomes w 2 different starting doses of lenvatinib in combination w everolimus for previously treated RCC Grateful for this opportunity @montypal @OncJournal @DrDanielHeng @docjavip @cdanicas https://t.co/eJ3z4eA5oq (@crisbergerot)
10 months ago
everolimus • Lenvima (lenvatinib)
10ms
Eric A. Singer, MD, discusses the #FDA approval of adjuvant sunitinib and data that support the approval for patients with high-risk renal cell carcinoma. #RCC #kcsm | @eric_facs @OSUCCC_James https://t.co/qaR5uc0Poh (@TargetedOnc)
10 months ago
Clinical • FDA event
|
Sutent (sunitinib)
10ms
Pembro & Lenvatinib can be challenging: Was there any toxicity data? Worried about this in a relapsed mesothelioma patient group (@tnewsomdavis)
10 months ago
Clinical
|
Keytruda (pembrolizumab) • Lenvima (lenvatinib)
10ms
💊Un estudi de Vall d’Hebron avala l’ús d’un nou fàrmac oral per a pacients amb càncer colorectal metastàtic refractari 👉"Els resultats de FRESCO-2 demostren l’eficàcia i la seguretat de fruquintinib", explica @TaberneroJosep, director del @VHIO https://t.co/iZXkAuTz0x (@DiariSanitat)
10 months ago
Fruzaqla (fruquintinib)
10ms
#ASCO23 | Giuseppe Procopio ha commentato per noi i dati a conferma dei benefici in PFS e OS di #pembrolizumab + #axitinib nel trattamento del #RCC metastatico. https://t.co/fGneVH0Qrl #KEYNOTE426 @gippo27 @IstTumori (@Oncoinfo_it)
10 months ago
Metastases
|
Keytruda (pembrolizumab) • Inlyta (axitinib)
10ms
At @ASCO23, @DrRanaMcKay met with @ChungHanLee3 to discuss the latest data on KEYNOTE-B61 for first-line #lenvatinib plus pembrolizumab for non-clear cell renal cell carcinoma. Watch now: https://t.co/awjZeCxkRb (@GUOncologyNow)
10 months ago
Clinical
|
Keytruda (pembrolizumab) • Lenvima (lenvatinib)
10ms
Exactly, often "not enough events occurred at time of data cut off for difference in OS to reach statistical significance" is reported as "no difference in OS". In GU, S-TRAC of adjuvant sunitinib in RCC clearly fits the definition in the slide, but others are more nuanced. (@AtishChoudhury)
10 months ago
Clinical
|
Sutent (sunitinib)
10ms
8/19 #TumorBoardTuesday #Sarcoma 👩🏻🏫Mini tweetorial 5👨🏻🏫 📰 Extra! Extra! 📰 ⬆️ TTP with sunitinib (SU) vs placebo 👍🏽 FDA approves SU for IM-resistant unresectable/adv #GIST 📚@DrSarcoma @CFletcherMD https://t.co/lspox5XwDG (@SteveBialickDO)
10 months ago
Clinical • FDA event
|
Sutent (sunitinib)
10ms
👏🏾Congratulations Dr. @CathyEngMD! Options in the continuum of care continue to grow for patients with #ColorectalCancer. G12C⛔️ & FRUquintinib to be added soon. 💡In future, do you see FRUquintinib being explored with chemo, or more so with novel drugs like the other TKIs💊? https://t.co/XGbU5ZmhFm (@pashtoonkasi)
10 months ago
Clinical
|
Fruzaqla (fruquintinib)
10ms
Comparing the cost-effectiveness of immunotherapy-based regimens and sunitinib in treating metastatic #RenalCellCarcinoma from a public payer perspective. Manish Kohli, MD @huntsmancancer joins @PBarataMD @caseccc to discuss on UroToday > https://t.co/pKTfVnYEGL @JCOOP_ASCO (@urotoday)
10 months ago
Clinical • HEOR • Cost effectiveness • Metastases
|
Sutent (sunitinib)
10ms
JUST OUT! Honored to serve as the senior author in @TheLancet re: Phase 3 FRESCO-2 #fruquintinib with improved OS and PFS. https://t.co/uFRInZDMZx Just a joy to work with @adasarimd @MDAndersonNews @hutchmed @TakedaOncology. @VUMCDiscoveries @VUMC_Cancer #crcsm #CancerResearch (@CathyEngMD)
10 months ago
Fruzaqla (fruquintinib)
10ms
At #ASCO23, @WallisCJD interviewed @brian_rini on an abstract focused on KEYNOTE-426, which revealed long-term survival data on pembrolizumab plus axitinib versus sunitinib as first-line therapy for advanced clear cell #RCC. Watch now: https://t.co/mUQplYnsxo (@GUOncologyNow)
10 months ago
Clinical • Interview • Metastases
|
Keytruda (pembrolizumab) • Sutent (sunitinib) • Inlyta (axitinib)
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