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BIOMARKER:
UGT1A1*1*1
i
Other names:
UGT1A1, UDP glucuronosyltransferase family 1 member A1, GNT1, UGT1, UDPGT, UGT1A, HUG-BR1, BILIQTL1, UDPGT 1-1
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Entrez ID:
54658
Related biomarkers:
Mutation
‹
›
Associations
(2)
News
Trials
Search handles
@GIcancerDoc
@KidneyCancerDoc
@dawood_findakly
@mtmdphd
@pashtoonkasi
Search handles
@GIcancerDoc
@KidneyCancerDoc
@dawood_findakly
@mtmdphd
@pashtoonkasi
Filter by
Latest
1year
Dual deficiency of DPD and UGT1A1 in a case of colon cancer [Nov 18, 2020] Rawlley et al. @anup_kasi Pharmacogenomics @futuresciencegp https://t.co/v0dKwYf5Bx #PrecisionMedicine #crcsm (@mtmdphd)
1 year ago
UGT1A1 (UDP glucuronosyltransferase family 1 member A1)
|
UGT1A1*1*1
over1year
#Irinotecan... #UGT1A1 genotypes... impact on toxicity... SN-38 metabolite... grade ≥3 neutropenia and/or Diarrhea... dose-dependent association... future pharmacokinetic models... #PancreaticCancer #GICancer #ONCO #Cancer #Onctwitter #Medtwitter #oncology #pancsm #bcsm #CRCSM (@dawood_findakly)
over 1 year ago
PK/PD data
|
UGT1A1 (UDP glucuronosyltransferase family 1 member A1)
|
UGT1A1*1*1
|
irinotecan
over1year
Dual deficiency of DPD and UGT1A1 in a case of colon cancer [Nov 18, 2020] Rawlley et al. @anup_kasi Pharmacogenomics @futuresciencegp https://t.co/v0dKwYfDr5 #PrecisionMedicine #crcsm (@mtmdphd)
over 1 year ago
UGT1A1 (UDP glucuronosyltransferase family 1 member A1)
|
UGT1A1*1*1
over1year
Dual deficiency of DPD and UGT1A1 in a case of colon cancer [Nov 18, 2020] Rawlley et al. @anup_kasi Pharmacogenomics @futuresciencegp https://t.co/v0dKwYf5Bx #PrecisionMedicine #crcsm (@mtmdphd)
over 1 year ago
UGT1A1 (UDP glucuronosyltransferase family 1 member A1)
|
UGT1A1*1*1
2years
Emerging therapies in bladder cancer & key toxicities: -EV: skin, neuropathy (in 50%), DKA (exclude A1c>8), pneumonitis 🫁, infusion rxn, ocular 👁 -Saci: neutropenia (⬆️ w UGT1A1), diarrhea 💩, N/V, HS -Erdafitinib: hyperPO4 (daily PO4 600-800mg rec), ocular 👁 #GU22 (@DrKarineTawagi)
2 years ago
UGT1A1 (UDP glucuronosyltransferase family 1 member A1)
|
UGT1A1*1*1
|
Balversa (erdafitinib)
2years
pharmacogenomics exciting area to identify and dose modify to limit toxicity - i was aware of DPYD data and now UGT1A1 for Sacituzumab -time to start adding these to our NGS panels for those with advanced disease!? #gu22 great talk by Tom Flaig (@KidneyCancerDoc)
2 years ago
Next-generation sequencing
|
UGT1A1 (UDP glucuronosyltransferase family 1 member A1) • DPYD (Dihydropyrimidine Dehydrogenase)
|
UGT1A1*1*1
over2years
"The #UGT1A1*28 status had no significant impact on the PKs of liposomal irinotecan" in: Population pharmacokinetics of liposomal irinotecan and exposure–safety analyses in patients with metastatic #PancreaticCancer https://t.co/SGRip3chhJ (@GIcancerDoc)
over 2 years ago
Clinical • PK/PD data
|
UGT1A1 (UDP glucuronosyltransferase family 1 member A1)
|
UGT1A1*28 • UGT1A1*1*1
over2years
Not in #CRCSM #colorectalcancer. The FOLFIRINOX regimen ē the nanoliposomal CPT-11 & ⬇️oxaliplatin I believe was presented in #PANCSM. I think 180 mg/m2 dose is high to start off. In palliative 150mg/m2; UGT1A1? Or start low/escalate as tolerated, which we did for our patient. 👇🏾 (@pashtoonkasi)
over 2 years ago
Clinical
|
UGT1A1 (UDP glucuronosyltransferase family 1 member A1)
|
UGT1A1*1*1
|
5-fluorouracil • oxaliplatin • irinotecan • leucovorin calcium
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