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BIOMARKER:
TSC1 mutation
i
Other names:
TSC1, TSC Complex Subunit 1, Tuberous Sclerosis 1 Protein, TSC, Tuberous Sclerosis 1, Truncated Hemartin, KIAA0243, LAM
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Entrez ID:
64930
Related biomarkers:
Mutation
CNA
‹
TSC1 deletion (2)
TSC1 deletion (1)
TSC1 deletion (2)
TSC1 deletion (1)
›
Associations
(6)
News
Trials
Search handles
@sonpavde
Search handles
@sonpavde
Filter by
Latest
1year
We report on 2 cases of exceptional response to combination gemcitabine+sirolimus after failure of nab-sirolimus and gemcitabine mono in TSC-mutated #sarcoma ↪️Molecular rationale support combination of these drugs! @MDAndersonNews @NeetaSomaiahMD https://t.co/rlbr0c1lqM (@NassifElise)
1 year ago
Clinical
|
TSC1 (TSC complex subunit 1)
|
TSC1 mutation
|
gemcitabine • Fyarro (nanoparticle albumin-bound rapamycin)
over1year
The sirolimus albumin-bound nanoparticles for injectable suspension demonstrated strong efficacy signals for the treatment of sarcomas with TSC1/2 gene mutations. @schulte_md @AgulnikMd @ucsfhealth @cityofhope #scmsm https://t.co/aPfHw7Oerw (@OncLive)
over 1 year ago
Clinical
|
TSC1 (TSC complex subunit 1)
|
TSC1 mutation
|
sirolimus
over1year
Investigators Unpack Role of Nab-Sirolimus for Solid Tumors With TSC1/2 Mutations @schulte_md @AgulnikMd @ucsfhealth @cityofhope #scmsm #oncology https://t.co/uIs7mnKbiz (@OncLiveSOSS)
over 1 year ago
TSC1 (TSC complex subunit 1)
|
TSC1 mutation
|
Fyarro (nanoparticle albumin-bound rapamycin)
almost3years
ESC-RCC, AE1/AE3, TSC1/TSC2 mutation. EVT, CK7, TSC/mTOR mutation (@SumantaDas_7)
almost 3 years ago
mTOR (Mechanistic target of rapamycin kinase) • TSC2 (TSC complex subunit 2) • TSC1 (TSC complex subunit 1)
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TSC1 mutation • TSC2 mutation • MTOR mutation
3years
Everolimus-low response rate (7%) in pan-cancer mutation+ (TSC1, TSC2, TSC1+TSC2, mTOR) basket study (n=30)-1 of 2 with response had upper tract #urothelialcarcinoma with biallelic TSC1 alteration + high TMB: @danafarber @sloan_kettering #DrKwiatkowski https://t.co/OYkmMUWhwD (@sonpavde)
3 years ago
Pan tumor
|
TMB (Tumor Mutational Burden) • mTOR (Mechanistic target of rapamycin kinase) • TSC2 (TSC complex subunit 2) • TSC1 (TSC complex subunit 1)
|
TMB-H • TSC1 mutation • TSC2 mutation • MTOR mutation
|
everolimus
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