^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    BIOMARKER:

    TSC1 mutation

    i
    Other names: TSC1, TSC Complex Subunit 1, Tuberous Sclerosis 1 Protein, TSC, Tuberous Sclerosis 1, Truncated Hemartin, KIAA0243, LAM
    Entrez ID:
    64930
    Related biomarkers:
    Mutation
    CNA
    1year
    We report on 2 cases of exceptional response to combination gemcitabine+sirolimus after failure of nab-sirolimus and gemcitabine mono in TSC-mutated #sarcoma ↪️Molecular rationale support combination of these drugs! @MDAndersonNews @NeetaSomaiahMD https://t.co/rlbr0c1lqM (@NassifElise)
    Clinical
    |
    TSC1 (TSC complex subunit 1)
    |
    TSC1 mutation
    |
    gemcitabine • Fyarro (nanoparticle albumin-bound rapamycin)
    1year
    The sirolimus albumin-bound nanoparticles for injectable suspension demonstrated strong efficacy signals for the treatment of sarcomas with TSC1/2 gene mutations. @schulte_md @AgulnikMd @ucsfhealth @cityofhope #scmsm https://t.co/aPfHw7Oerw (@OncLive)
    Clinical
    |
    TSC1 (TSC complex subunit 1)
    |
    TSC1 mutation
    |
    sirolimus
    1year
    Investigators Unpack Role of Nab-Sirolimus for Solid Tumors With TSC1/2 Mutations @schulte_md @AgulnikMd @ucsfhealth @cityofhope #scmsm #oncology https://t.co/uIs7mnKbiz (@OncLiveSOSS)
    TSC1 (TSC complex subunit 1)
    |
    TSC1 mutation
    |
    Fyarro (nanoparticle albumin-bound rapamycin)
    almost3years
    ESC-RCC, AE1/AE3, TSC1/TSC2 mutation. EVT, CK7, TSC/mTOR mutation (@SumantaDas_7)
    mTOR (Mechanistic target of rapamycin kinase) • TSC2 (TSC complex subunit 2) • TSC1 (TSC complex subunit 1)
    |
    TSC1 mutation • TSC2 mutation • MTOR mutation
    3years
    Everolimus-low response rate (7%) in pan-cancer mutation+ (TSC1, TSC2, TSC1+TSC2, mTOR) basket study (n=30)-1 of 2 with response had upper tract #urothelialcarcinoma with biallelic TSC1 alteration + high TMB: @danafarber @sloan_kettering #DrKwiatkowski https://t.co/OYkmMUWhwD (@sonpavde)
    Pan tumor
    |
    TMB (Tumor Mutational Burden) • mTOR (Mechanistic target of rapamycin kinase) • TSC2 (TSC complex subunit 2) • TSC1 (TSC complex subunit 1)
    |
    TMB-H • TSC1 mutation • TSC2 mutation • MTOR mutation
    |
    everolimus