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BIOMARKER:
TROP2 overexpression
i
Other names:
TROP2, Trophoblast Cell Surface Antigen 2, Tumor Associated Calcium Signal Transducer 2, Membrane Component Chromosome 1 Surface Marker 1, Tumor-Associated Calcium Signal Transducer 2, Pancreatic Carcinoma Marker Protein GA733-1, Cell Surface Glycoprotein Trop-2, Epithelial Glycoprotein-1, GA733-1, M1S1, Gastrointestinal Tumor-Associated Antigen GA733, Pancreatic Carcinoma Marker Protein GA7331, Cell Surface Glycoprotein TROP2, Truncated TACSTD2, GA7331, EGP-1, GP50 , TACSTD2
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Entrez ID:
4070
Related biomarkers:
Expression
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Associations
(7)
News
Trials
Search handles
@ChristianRolfo
@chulkimMD
Search handles
@ChristianRolfo
@chulkimMD
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Latest
3years
TROP2 overexpression is per se a negative prognostic factor in Bladder, breast and lung cancer, so it’s an unmet medical need for solid tumors. Activity was shown in trials regardless expression stratification. breast cancer seems to be more evolved in this research certainly (@ChristianRolfo)
3 years ago
TROP2 (Trophoblast Cell Surface Antigen 2)
|
TROP2 expression • TROP2 overexpression
3years
Ph 1 study of datopotamab deruxtecan, TROP2 ADC. TROP2 highly expressed in NSCLC. AEs mainly nonhematologic including 8% ILD. ORR 20% at MTD (8 mg/kg Q3W). Ph 3 trial Dato-DXd (6 mg/kg Q3W) vs docetaxel ongoing. Q:TROP2 expression predictor of response? #wclc2020 @AlexSpiraMDPhD (@chulkimMD)
3 years ago
TROP2 (Trophoblast Cell Surface Antigen 2)
|
TROP2 expression • TROP2 overexpression
|
docetaxel • datopotamab deruxtecan (DS-1062a)
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