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BIOMARKER:
TP53 expression
i
Other names:
TP53, Tumor Protein P53, Cellular Tumor Antigen P53, Phosphoprotein P53, Tumor Protein P53, Antigen NY-CO-13, Transformation-Related Protein 53, Mutant Tumor Protein 53, P53 Tumor Suppressor, Tumor Suppressor P53, Tumor Protein 53, BMFS5, TRP53, BCC7, LFS1
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Entrez ID:
7157
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
TP53 mutation + Chr del(17p) (14)
FGF19 amplification + HRAS Q61R + TP53 672+2T>G (6)
FGF3 amplification + HRAS Q61R + TP53 672+2T>G (6)
FGF4 amplification + HRAS Q61R + TP53 672+2T>G (6)
EML4-ALK variant 3 + TP53 mutation (5)
TP53 mutation + ALK positive (4)
BRCA wild-type + TP53 mutation (3)
TP53 mutation + Chr del(11q) (3)
ALK fusion + TP53 mutation (2)
EGFR exon 19 deletion + TP53 mutation + RB1 mutation (2)
EML4-ALK fusion + TP53 mutation (2)
HR positive + TP53 mutation (2)
ALK fusion + EML4-ALK variant 3 + TP53 mutation (1)
ALK negative + TP53 deletion (1)
ALK positive + EML4-ALK fusion + TP53 mutation (1)
CD74-ROS1 fusion + TP53 mutation (1)
CPE-ALK fusion + TP53 wild-type (1)
Chr del(5q) + TP53 expression (1)
Chr t(11;14) + TP53 mutation (1)
EGFR exon 19 deletion + EGFR exon 21 mutation + TP53 mutation (1)
EGFR exon 19 deletion + TP53 mutation + CDK6 amplification + KRAS amplification (1)
EGFR exon 19 deletion + TP53 mutation + MET amplification (1)
EGFR exon 20 insertion + TP53 mutation (1)
EGFR expression + TP53 mutation (1)
EGFR mutation + MET amplification + TP53 mutation (1)
EGFR mutation + PD-L1 expression + TP53 mutation (1)
EGFR mutation + TP53 expression (1)
FAT1 mutation + TP53 wild-type (1)
FLT3 wild-type + TP53 mutation (1)
FLT3-ITD mutation + MLL fusion + TP53 mutation (1)
GNA13 deletion + TP53 mutation (1)
HER-2 positive + TP53 mutation (1)
HRAS Q61R + TP53 P278S + PD-L1 overexpression (1)
IDH wild-type + FGFR3 S249C + TP53 V73fs (1)
IDH1 mutation + ATRX deletion + TP53 deletion (1)
KDR amplification + FLT4 amplification + MCL1 amplification + TP53 R213 + TP53 H179Y + ARID1A Q2128 (1)
KIF5B-RET fusion + TP53 H193R + MYC amplification (1)
KRAS G12D + TP53 deletion (1)
KRAS mutation + TP53 mutation + GNA13 deletion (1)
KRAS mutation + TP53 mutation + PD-L1 expression + PD-1 expression (1)
LDH elevation + TP53 mutation (1)
LRP1B mutation + TP53 wild-type (1)
MDM2 amplification + TP53 wild-type (1)
MDM2 amplification + TP53 wild-type + TWIST1 amplification (1)
MET amplification + TP53 mutation (1)
MET amplification + TP53 mutation + SMAD4 mutation + CTNNA1 mutation (1)
MSI-H/dMMR + TP53 mutation (1)
MSLN overexpression + TP53 mutation (1)
PD-L1 overexpression + KRAS G12C + TP53 mutation (1)
PD-L1 overexpression + RET-KIF5B fusion + TP53 mutation + AR mutation + RET rearrangement (1)
ROS1 fusion + TP53 mutation (1)
ROS1-CD74 fusion + TP53 K139N (1)
SQSTM1-NTRK1 + PIK3CA E545K + TP53 L145R + PD-L1 overexpression (1)
STK11 mutation + KRAS mutation + TP53 deletion (1)
TMB-H + RB1 L518fs*6 + ERCC4 R799W + TP53 C124* (1)
TMEM87A-RASGRF1 fusion + TP53 R273H (1)
TP53 R280K + BRCA wild-type (1)
TP53 S12F + KRAS G12D + TMB-L (1)
TP53 deletion + RB1 deletion + CTSK expression (1)
TP53 mutation + FANCM mutation + TMB-H (1)
TP53 mutation + FGFR2 fusion (1)
TP53 mutation + LRP1B mutation + TMB-H (1)
TP53 mutation + MET amplification + PD-L1 overexpression (1)
TP53 mutation + PD-L1 expression (1)
TP53 mutation + PD-L1 negative (1)
TP53 mutation + TMB-H + PD-L1 overexpression (1)
TP53 wild-type + ER positive (1)
FGFR2 K660N + TP53 deletion (0)
TP53 mutation + Chr del(17p) (14)
FGF19 amplification + HRAS Q61R + TP53 672+2T>G (6)
FGF3 amplification + HRAS Q61R + TP53 672+2T>G (6)
FGF4 amplification + HRAS Q61R + TP53 672+2T>G (6)
EML4-ALK variant 3 + TP53 mutation (5)
TP53 mutation + ALK positive (4)
BRCA wild-type + TP53 mutation (3)
TP53 mutation + Chr del(11q) (3)
ALK fusion + TP53 mutation (2)
EGFR exon 19 deletion + TP53 mutation + RB1 mutation (2)
EML4-ALK fusion + TP53 mutation (2)
HR positive + TP53 mutation (2)
ALK fusion + EML4-ALK variant 3 + TP53 mutation (1)
ALK negative + TP53 deletion (1)
ALK positive + EML4-ALK fusion + TP53 mutation (1)
CD74-ROS1 fusion + TP53 mutation (1)
CPE-ALK fusion + TP53 wild-type (1)
Chr del(5q) + TP53 expression (1)
Chr t(11;14) + TP53 mutation (1)
EGFR exon 19 deletion + EGFR exon 21 mutation + TP53 mutation (1)
EGFR exon 19 deletion + TP53 mutation + CDK6 amplification + KRAS amplification (1)
EGFR exon 19 deletion + TP53 mutation + MET amplification (1)
EGFR exon 20 insertion + TP53 mutation (1)
EGFR expression + TP53 mutation (1)
EGFR mutation + MET amplification + TP53 mutation (1)
EGFR mutation + PD-L1 expression + TP53 mutation (1)
EGFR mutation + TP53 expression (1)
FAT1 mutation + TP53 wild-type (1)
FLT3 wild-type + TP53 mutation (1)
FLT3-ITD mutation + MLL fusion + TP53 mutation (1)
GNA13 deletion + TP53 mutation (1)
HER-2 positive + TP53 mutation (1)
HRAS Q61R + TP53 P278S + PD-L1 overexpression (1)
IDH wild-type + FGFR3 S249C + TP53 V73fs (1)
IDH1 mutation + ATRX deletion + TP53 deletion (1)
KDR amplification + FLT4 amplification + MCL1 amplification + TP53 R213 + TP53 H179Y + ARID1A Q2128 (1)
KIF5B-RET fusion + TP53 H193R + MYC amplification (1)
KRAS G12D + TP53 deletion (1)
KRAS mutation + TP53 mutation + GNA13 deletion (1)
KRAS mutation + TP53 mutation + PD-L1 expression + PD-1 expression (1)
LDH elevation + TP53 mutation (1)
LRP1B mutation + TP53 wild-type (1)
MDM2 amplification + TP53 wild-type (1)
MDM2 amplification + TP53 wild-type + TWIST1 amplification (1)
MET amplification + TP53 mutation (1)
MET amplification + TP53 mutation + SMAD4 mutation + CTNNA1 mutation (1)
MSI-H/dMMR + TP53 mutation (1)
MSLN overexpression + TP53 mutation (1)
PD-L1 overexpression + KRAS G12C + TP53 mutation (1)
PD-L1 overexpression + RET-KIF5B fusion + TP53 mutation + AR mutation + RET rearrangement (1)
ROS1 fusion + TP53 mutation (1)
ROS1-CD74 fusion + TP53 K139N (1)
SQSTM1-NTRK1 + PIK3CA E545K + TP53 L145R + PD-L1 overexpression (1)
STK11 mutation + KRAS mutation + TP53 deletion (1)
TMB-H + RB1 L518fs*6 + ERCC4 R799W + TP53 C124* (1)
TMEM87A-RASGRF1 fusion + TP53 R273H (1)
TP53 R280K + BRCA wild-type (1)
TP53 S12F + KRAS G12D + TMB-L (1)
TP53 deletion + RB1 deletion + CTSK expression (1)
TP53 mutation + FANCM mutation + TMB-H (1)
TP53 mutation + FGFR2 fusion (1)
TP53 mutation + LRP1B mutation + TMB-H (1)
TP53 mutation + MET amplification + PD-L1 overexpression (1)
TP53 mutation + PD-L1 expression (1)
TP53 mutation + PD-L1 negative (1)
TP53 mutation + TMB-H + PD-L1 overexpression (1)
TP53 wild-type + ER positive (1)
FGFR2 K660N + TP53 deletion (0)
›
Associations
(4)
News
Trials
Search handles
@AlkaliDr
@Anand_88_Patel
@StephenVLiu
Search handles
@AlkaliDr
@Anand_88_Patel
@StephenVLiu
Filter by
Latest
1year
Diverse chromosomal alterations converge on similar expression changes in TP53 deficient gastric cancer model. #AACR23 (@AZBioMarkers)
1 year ago
TP53 (Tumor protein P53)
|
TP53 expression
1year
3/3 We evaluated TP53 expression in 6,700 ovarian tumours (that's why consortia needed) and show that levels of expression is not associated with prognosis in high-grade serous, but high levels of expression is associated with poorer prognosis in endometrioid and clear cell. (@paulpharoah)
1 year ago
TP53 (Tumor protein P53)
|
TP53 expression
over1year
#Pure_Erythroid_Leukemia and multi-hit tp53 alteration @TapKadia #AMLsm #AML_M6 Pure erythroid leukemia is characterized by biallelic <i>TP53</i> inactivation and abnormal p53 expression patterns in <i>de novo</i> and secondary cases | Haematologica https://t.co/xTqzZgrH1p (@AlkaliDr)
over 1 year ago
Clinical
|
TP53 (Tumor protein P53)
|
TP53 expression
2years
And Day 14! TP53-mutated AML #leusm multi-center analysis of outcomes of TP53-mutated AML @TalhaBadarMD: https://t.co/nFlqRNfXSm protein expression of p53 by IHC and TP53 copy-number loss informs mutation status in AML @TashakoriM: https://t.co/7nm0M97YI3 (@Anand_88_Patel)
2 years ago
Clinical
|
TP53 (Tumor protein P53)
|
TP53 mutation • TP53 expression
over2years
Very interesting. I'm happy to admit morphological criteria of dysplasia are much more difficult and subjective than assessing p53 expression. This sounds good and logical, hope it helps bringing down the incidence of esophageal adenocarcinoma. (@DraEosina)
over 2 years ago
TP53 (Tumor protein P53)
|
TP53 expression
over2years
#PTTO2021 Great talk by Dr. @HelenaYu923 on #EGFR transformed #SCLC. Tend to lose EGFR protein expression. RB1 and TP53 predict transformation (though even when lost, SCLC transformation is a minority). Poor outcomes with IO. Can we prevent transformation with early intervention? (@StephenVLiu)
over 2 years ago
EGFR (Epidermal growth factor receptor) • TP53 (Tumor protein P53) • RB1 (RB Transcriptional Corepressor 1)
|
EGFR expression • TP53 expression
almost4years
Elevated MCOLN1 Expression in p53-Deficient Bladder Cancer is Necessary for Oncogene-Induced Cell proliferation, Inflammation, and Invasion | bioRxiv @sonpavde https://t.co/fdqRZVDrnl (@drleighellis)
almost 4 years ago
TP53 (Tumor protein P53)
|
TP53 expression
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