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BIOMARKER:
TP53 deletion
i
Other names:
TP53, Tumor Protein P53, Cellular Tumor Antigen P53, Phosphoprotein P53, Tumor Protein P53, Antigen NY-CO-13, Transformation-Related Protein 53, Mutant Tumor Protein 53, P53 Tumor Suppressor, Tumor Suppressor P53, Tumor Protein 53, BMFS5, TRP53, BCC7, LFS1
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Entrez ID:
7157
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
TP53 mutation + Chr del(17p) (14)
FGF19 amplification + HRAS Q61R + TP53 672+2T>G (6)
FGF3 amplification + HRAS Q61R + TP53 672+2T>G (6)
FGF4 amplification + HRAS Q61R + TP53 672+2T>G (6)
EML4-ALK variant 3 + TP53 mutation (5)
TP53 mutation + ALK positive (4)
BRCA wild-type + TP53 mutation (3)
TP53 mutation + Chr del(11q) (3)
ALK fusion + TP53 mutation (2)
EGFR exon 19 deletion + TP53 mutation + RB1 mutation (2)
EML4-ALK fusion + TP53 mutation (2)
HR positive + TP53 mutation (2)
ALK fusion + EML4-ALK variant 3 + TP53 mutation (1)
ALK negative + TP53 deletion (1)
ALK positive + EML4-ALK fusion + TP53 mutation (1)
CD74-ROS1 fusion + TP53 mutation (1)
CPE-ALK fusion + TP53 wild-type (1)
Chr del(5q) + TP53 expression (1)
Chr t(11;14) + TP53 mutation (1)
EGFR exon 19 deletion + EGFR exon 21 mutation + TP53 mutation (1)
EGFR exon 19 deletion + TP53 mutation + CDK6 amplification + KRAS amplification (1)
EGFR exon 19 deletion + TP53 mutation + MET amplification (1)
EGFR exon 20 insertion + TP53 mutation (1)
EGFR expression + TP53 mutation (1)
EGFR mutation + MET amplification + TP53 mutation (1)
EGFR mutation + PD-L1 expression + TP53 mutation (1)
EGFR mutation + TP53 expression (1)
FAT1 mutation + TP53 wild-type (1)
FLT3 wild-type + TP53 mutation (1)
FLT3-ITD mutation + MLL fusion + TP53 mutation (1)
GNA13 deletion + TP53 mutation (1)
HER-2 positive + TP53 mutation (1)
HRAS Q61R + TP53 P278S + PD-L1 overexpression (1)
IDH wild-type + FGFR3 S249C + TP53 V73fs (1)
IDH1 mutation + ATRX deletion + TP53 deletion (1)
KDR amplification + FLT4 amplification + MCL1 amplification + TP53 R213 + TP53 H179Y + ARID1A Q2128 (1)
KIF5B-RET fusion + TP53 H193R + MYC amplification (1)
KRAS G12D + TP53 deletion (1)
KRAS mutation + TP53 mutation + GNA13 deletion (1)
KRAS mutation + TP53 mutation + PD-L1 expression + PD-1 expression (1)
LDH elevation + TP53 mutation (1)
LRP1B mutation + TP53 wild-type (1)
MDM2 amplification + TP53 wild-type (1)
MDM2 amplification + TP53 wild-type + TWIST1 amplification (1)
MET amplification + TP53 mutation (1)
MET amplification + TP53 mutation + SMAD4 mutation + CTNNA1 mutation (1)
MSI-H/dMMR + TP53 mutation (1)
MSLN overexpression + TP53 mutation (1)
PD-L1 overexpression + KRAS G12C + TP53 mutation (1)
PD-L1 overexpression + RET-KIF5B fusion + TP53 mutation + AR mutation + RET rearrangement (1)
ROS1 fusion + TP53 mutation (1)
ROS1-CD74 fusion + TP53 K139N (1)
SQSTM1-NTRK1 + PIK3CA E545K + TP53 L145R + PD-L1 overexpression (1)
STK11 mutation + KRAS mutation + TP53 deletion (1)
TMB-H + RB1 L518fs*6 + ERCC4 R799W + TP53 C124* (1)
TMEM87A-RASGRF1 fusion + TP53 R273H (1)
TP53 R280K + BRCA wild-type (1)
TP53 S12F + KRAS G12D + TMB-L (1)
TP53 deletion + RB1 deletion + CTSK expression (1)
TP53 mutation + FANCM mutation + TMB-H (1)
TP53 mutation + FGFR2 fusion (1)
TP53 mutation + LRP1B mutation + TMB-H (1)
TP53 mutation + MET amplification + PD-L1 overexpression (1)
TP53 mutation + PD-L1 expression (1)
TP53 mutation + PD-L1 negative (1)
TP53 mutation + TMB-H + PD-L1 overexpression (1)
TP53 wild-type + ER positive (1)
FGFR2 K660N + TP53 deletion (0)
TP53 mutation + Chr del(17p) (14)
FGF19 amplification + HRAS Q61R + TP53 672+2T>G (6)
FGF3 amplification + HRAS Q61R + TP53 672+2T>G (6)
FGF4 amplification + HRAS Q61R + TP53 672+2T>G (6)
EML4-ALK variant 3 + TP53 mutation (5)
TP53 mutation + ALK positive (4)
BRCA wild-type + TP53 mutation (3)
TP53 mutation + Chr del(11q) (3)
ALK fusion + TP53 mutation (2)
EGFR exon 19 deletion + TP53 mutation + RB1 mutation (2)
EML4-ALK fusion + TP53 mutation (2)
HR positive + TP53 mutation (2)
ALK fusion + EML4-ALK variant 3 + TP53 mutation (1)
ALK negative + TP53 deletion (1)
ALK positive + EML4-ALK fusion + TP53 mutation (1)
CD74-ROS1 fusion + TP53 mutation (1)
CPE-ALK fusion + TP53 wild-type (1)
Chr del(5q) + TP53 expression (1)
Chr t(11;14) + TP53 mutation (1)
EGFR exon 19 deletion + EGFR exon 21 mutation + TP53 mutation (1)
EGFR exon 19 deletion + TP53 mutation + CDK6 amplification + KRAS amplification (1)
EGFR exon 19 deletion + TP53 mutation + MET amplification (1)
EGFR exon 20 insertion + TP53 mutation (1)
EGFR expression + TP53 mutation (1)
EGFR mutation + MET amplification + TP53 mutation (1)
EGFR mutation + PD-L1 expression + TP53 mutation (1)
EGFR mutation + TP53 expression (1)
FAT1 mutation + TP53 wild-type (1)
FLT3 wild-type + TP53 mutation (1)
FLT3-ITD mutation + MLL fusion + TP53 mutation (1)
GNA13 deletion + TP53 mutation (1)
HER-2 positive + TP53 mutation (1)
HRAS Q61R + TP53 P278S + PD-L1 overexpression (1)
IDH wild-type + FGFR3 S249C + TP53 V73fs (1)
IDH1 mutation + ATRX deletion + TP53 deletion (1)
KDR amplification + FLT4 amplification + MCL1 amplification + TP53 R213 + TP53 H179Y + ARID1A Q2128 (1)
KIF5B-RET fusion + TP53 H193R + MYC amplification (1)
KRAS G12D + TP53 deletion (1)
KRAS mutation + TP53 mutation + GNA13 deletion (1)
KRAS mutation + TP53 mutation + PD-L1 expression + PD-1 expression (1)
LDH elevation + TP53 mutation (1)
LRP1B mutation + TP53 wild-type (1)
MDM2 amplification + TP53 wild-type (1)
MDM2 amplification + TP53 wild-type + TWIST1 amplification (1)
MET amplification + TP53 mutation (1)
MET amplification + TP53 mutation + SMAD4 mutation + CTNNA1 mutation (1)
MSI-H/dMMR + TP53 mutation (1)
MSLN overexpression + TP53 mutation (1)
PD-L1 overexpression + KRAS G12C + TP53 mutation (1)
PD-L1 overexpression + RET-KIF5B fusion + TP53 mutation + AR mutation + RET rearrangement (1)
ROS1 fusion + TP53 mutation (1)
ROS1-CD74 fusion + TP53 K139N (1)
SQSTM1-NTRK1 + PIK3CA E545K + TP53 L145R + PD-L1 overexpression (1)
STK11 mutation + KRAS mutation + TP53 deletion (1)
TMB-H + RB1 L518fs*6 + ERCC4 R799W + TP53 C124* (1)
TMEM87A-RASGRF1 fusion + TP53 R273H (1)
TP53 R280K + BRCA wild-type (1)
TP53 S12F + KRAS G12D + TMB-L (1)
TP53 deletion + RB1 deletion + CTSK expression (1)
TP53 mutation + FANCM mutation + TMB-H (1)
TP53 mutation + FGFR2 fusion (1)
TP53 mutation + LRP1B mutation + TMB-H (1)
TP53 mutation + MET amplification + PD-L1 overexpression (1)
TP53 mutation + PD-L1 expression (1)
TP53 mutation + PD-L1 negative (1)
TP53 mutation + TMB-H + PD-L1 overexpression (1)
TP53 wild-type + ER positive (1)
FGFR2 K660N + TP53 deletion (0)
›
Associations
(21)
News
Trials
Search handles
@DrRaulCordoba
@RahulBanerjeeMD
Search handles
@DrRaulCordoba
@RahulBanerjeeMD
Filter by
Latest
11ms
@LeppaSM: TP53 deletions remained as the only high risk factor with impact in PFS and OS #lymsm. My question: how should we manage those patients? 🤔 #17ICML (@DrRaulCordoba)
11 months ago
Clinical
|
TP53 (Tumor protein P53)
|
TP53 deletion
over1year
Congrats @mmejia91 @RubenNiesvizky @WeillCornell on an awesome use of CoMpass @theMMRF data! Hadn’t seen this abstract. #ASH22 analysis of EMD in #MMsm showing higher rates of p53 deletion or inactivation. Unsurprisingly, higher Hgb and lower M-spike at Dx. (@RahulBanerjeeMD)
over 1 year ago
TP53 (Tumor protein P53)
|
TP53 deletion
2years
Our latest paper published in Oncogene. We found that myeloma cells with both p53 deletion and 1q21 amplification are susceptible to CHEK2 inhibition due to deregulated DNA damage response. This may offer a new approach for these high-risk patients. https://t.co/ez7t6SsslE #mmsm (@chngwj)
2 years ago
Clinical
|
CHEK2 (Checkpoint kinase 2)
|
TP53 deletion
over2years
#losemi hastalarında kemoimmunoterapi ile umut vaat eden gelişmeler %100’e varan yanıt ve 45 ayı aşan sağkalım #KLL #fevzialtuntas Durable remissions following combined targeted therapy in patients with CLL harboring TP53 deletions and/or mutations https://t.co/ZK02CViyl5. (@altuntasfevzi)
over 2 years ago
Clinical • NDA
|
TP53 (Tumor protein P53)
|
TP53 mutation • TP53 deletion
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