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    CANCER:

    Testicular Seminoma

    Related cancers:
    1m
    Discussion across GU malignancies to start day at #GU23 Biomarkers of response to Enfortumab Vedotin in UC, cabo/nivo in RCC, updated analysis of nivo/ipi of CRPC - high TMB not predictive of benefit and new clinical risk stratification for relapse in stage 1 seminoma @OncLive (@BradMcG04)
    Clinical
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    TMB (Tumor Mutational Burden)
    |
    TMB-H
    |
    Opdivo (nivolumab) • Yervoy (ipilimumab) • Cabometyx (cabozantinib tablet) • Padcev (enfortumab vedotin)
    9ms
    Seminoma & Embryonal Carcinoma in Transition Part 1: abrupt - note differences in cytoplasm and nuclear features & contrast in CD30 #IHC labeling #testicularcancer #gupath @TestesCancer (@rovingatuscap)
    TNFRSF8 (TNF Receptor Superfamily Member 8)
    over1year
    How often do you find scattered glypican 3 cells in pure seminomas? (@jackjacob)
    GPC3 (Glypican 3)
    over1year
    Testicular Seminoma #IHC upper R = OCT4(+) [nuclear] lower L = CD117 {c-kit} (+) [membranous] lower R = pancytokeratin AE1/AE3 🚨pancytokeratin (+) has linear or peri-nuclear hof pattern; not uncommon in seminoma & does not indicate carcinomatous transformation #gupath (@rovingatuscap)
    KIT (KIT proto-oncogene, receptor tyrosine kinase) • POU5F1 (POU Class 5 Homeobox 1)
    over1year
    Elderly male, testicular tumor. Seminoma (IHC: OCT4) was weird enough, separate mid-spermatic cord tumor nodule made the case remarkable. Vasitis nodosa. #gupath @Williamson_SR @LiangChengMD @GladellPaner @rovingatuscap @daniel_berney (@AkgulMd)
    POU5F1 (POU Class 5 Homeobox 1)