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    BIOMARKER:

    SRSF2 mutation

    i
    Other names: SRSF2, Serine And Arginine Rich Splicing Factor 2, Splicing Factor, Arginine/Serine-Rich 2, Serine/Arginine-Rich Splicing Factor 2, Splicing Factor SC35, Splicing Component, 35 KDa, SR Splicing Factor 2, SFRS2, Protein PR264, SFRS2A, SRp30b, PR264
    Entrez ID:
    6427
    Related biomarkers:
    Mutation
    10ms
    📍subgroup of MDS related gene mutations (ASXL1, SRSF2, SF3B1, STAG2, RUNX1, BCOR, EZH2, U2AF1 and ZRSR2) 👉🏻 OS: CPX-351 38.4 m vs Ida-FLAG 16.3 m #AML19 #AML19trial #MDS #AML @ASH_hematology @BloodAdvances @AML_Hub @jadothm (@DrJCornago)
    RUNX1 (RUNX Family Transcription Factor 1) • SF3B1 (Splicing Factor 3b Subunit 1) • ASXL1 (ASXL Transcriptional Regulator 1) • SRSF2 (Serine and arginine rich splicing factor 2) • BCOR (BCL6 Corepressor) • U2AF1 (U2 Small Nuclear RNA Auxiliary Factor 1) • STAG2 (Stromal Antigen 2) • ZRSR2 (Zinc Finger CCCH-Type, RNA Binding Motif And Serine/Arginine Rich 2)
    |
    SF3B1 mutation • SRSF2 mutation • U2AF1 mutation • STAG2 mutation
    |
    Vyxeos (cytarabine/daunorubicin liposomal formulation)
    10ms
    Co-occurring mutations in ASXL1, SRSF2, and SETBP1 in MDS/MPN with neutrophilia #mpnsm @mpdrc ... https://t.co/QxIFqNkim2 (@TaniaJain11)
    ASXL1 (ASXL Transcriptional Regulator 1) • SRSF2 (Serine and arginine rich splicing factor 2) • SETBP1 (SET Binding Protein 1)
    |
    ASXL1 mutation • SRSF2 mutation
    1year
    Some fun facts about CMML: TET2/SRSF2 mutations are initiating events but acquisition of ASXL-1, RUNX1, SF3B1 and DNMT3A mutations usually give rise to dysplastic CMML while ASXL1, JAK2 and RAS give rise to proliferative CMML. TP53 mutations are extremely rare in CMML ( <1%). (@Persian1010)
    TP53 (Tumor protein P53) • DNMT3A (DNA methyltransferase 1) • JAK2 (Janus kinase 2) • RUNX1 (RUNX Family Transcription Factor 1) • SF3B1 (Splicing Factor 3b Subunit 1) • ASXL1 (ASXL Transcriptional Regulator 1) • TET2 (Tet Methylcytosine Dioxygenase 2) • SRSF2 (Serine and arginine rich splicing factor 2) • RAS (Rat Sarcoma Virus)
    |
    TP53 mutation • DNMT3A mutation • TET2 mutation • SRSF2 mutation
    almost2years
    👉👉👉Our group’s new paper led by Dr ⁦@TashakoriM⁩ & Dr ⁦@sanamloghavi⁩ Clinicopathologic spectrum of myeloid neoplasms w/concurrent myeloproliferative neoplasm driver mutations and #SRSF2 mutations | ⁦@ModernPathology⁩ | #MPNSM #leusm https://t.co/zqf9hLoog3 (@doctorpemm)
    Clinical
    |
    SRSF2 (Serine and arginine rich splicing factor 2)
    |
    SRSF2 mutation
    over2years
    Share with me something you learned today #TheMoreYouKnow I learned that TET2, SRSF2, and ASXL1 are the most frequently mutates genes in CMML! It a nice little nugget to stamp in with the hippocampus. (@AaronGoodman33)
    ASXL1 (ASXL Transcriptional Regulator 1) • TET2 (Tet Methylcytosine Dioxygenase 2) • SRSF2 (Serine and arginine rich splicing factor 2)
    |
    ASXL1 mutation • SRSF2 mutation
    over2years
    A 56 y/o man w/ #AML (trisomy 8, mutations in ASXL1, SRSF2, IDH2, RUNX1) declined conventional therapy but achieved remission after 7 Kambô treatments (topical application of Phyllomedusa bicolor frog secretions). Which do you think is the most likely? https://t.co/0cm79uglGj (@DavidSteensma)
    Clinical
    |
    IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2) • RUNX1 (RUNX Family Transcription Factor 1) • ASXL1 (ASXL Transcriptional Regulator 1) • SRSF2 (Serine and arginine rich splicing factor 2)
    |
    IDH2 mutation • ASXL1 mutation • SRSF2 mutation
    almost3years
    ▶️ https://t.co/kxVWAenS4v Is Secondary #AML Associated w/Specific Mutations❓ "...the presence of what we call spliceosome mutations, & SRSF2, SF3B1, U2AF1, & others can be specifically linked to a secondary #AML origin..."@EuniceWangMD #meded #SoMe #MedTwitter #CME #CPE (@MediComOncology)
    SF3B1 (Splicing Factor 3b Subunit 1) • SRSF2 (Serine and arginine rich splicing factor 2) • U2AF1 (U2 Small Nuclear RNA Auxiliary Factor 1)
    |
    SF3B1 mutation • SRSF2 mutation • U2AF1 mutation
    3years
    1/ Splicing mutations (SRSF2, U2AF1, SF3B1, ZRSR2) are common in sAML, and correspond to inferior outcomes when identified in de novo AML @BloodJournal @Haematologica https://t.co/9460cvp2yu https://t.co/aABTHuPY5P (@CLachowiez)
    SF3B1 (Splicing Factor 3b Subunit 1) • SRSF2 (Serine and arginine rich splicing factor 2) • U2AF1 (U2 Small Nuclear RNA Auxiliary Factor 1)
    |
    SF3B1 mutation • SRSF2 mutation • U2AF1 mutation