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    BIOMARKER:

    RB1 deletion

    i
    Other names: RB1, Retinoblastoma 1, RB Transcriptional Corepressor 1, Protein Phosphatase 1, Regulatory Subunit 130, Prepro-Retinoblastoma-Associated Protein, Retinoblastoma-Associated Protein, Retinoblastoma-Associated Protein, Retinoblastoma Suspectibility Protein
    Entrez ID:
    5925
    Related biomarkers:
    Expression
    Mutation
    CNA
    Others
    over2years
    Reversal of lineage plasticity in RB1/TP53-deleted prostate cancer through FGFR and Janus kinase inhibition | bioRxiv https://t.co/HS3BrdRVIZ (@AnthonyMJoshua)
    TP53 (Tumor protein P53) • RB1 (RB Transcriptional Corepressor 1) • FGFR (Fibroblast Growth Factor Receptor)
    |
    RB1 deletion
    3years
    “3) lack of AR expression does not necessitate acquiring a NE phenotype despite concomitant mutations/deletions in PTEN and TP53, and loss of RB1, but can occur via emergence of an AR-/NE- double negative prostate cancer (DNPC)” 2/3 (@Dr_RaviMadan)
    TP53 (Tumor protein P53) • PTEN (Phosphatase and tensin homolog) • RB1 (RB Transcriptional Corepressor 1)
    |
    TP53 mutation • PTEN mutation • RB1 deletion • AR expression
    over3years
    Pharmacologically targetable vulnerability in prostate cancer carrying RB1-SUCLA2 deletion. https://t.co/X7B9NAPGmm ⁦@AdamSharpMedOnc⁩ ⁦@estherbaena⁩ ⁦@drleighellis⁩ ⁦@Heer_Lab⁩ (@HendryVictoria)
    RB1 (RB Transcriptional Corepressor 1)
    |
    RB1 deletion
    almost4years
    Thank you @DrPhilKantoff Great teamwork with @Dolmos77 & @Ecastromarcos as mentors! BRCA2-RB1 co-deletion seems to be an important prognostic factor in #ProstateCancer (@rebecaLozMe)
    BRCA2 (Breast cancer 2, early onset) • RB1 (RB Transcriptional Corepressor 1)
    |
    RB1 deletion