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    BIOMARKER:

    POLD1 mutation

    i
    Other names: DNA Polymerase Delta 1 Catalytic Subunit, Polymerase (DNA) Delta 1 Catalytic Subunit, DNA Polymerase Delta Catalytic Subunit, DNA Polymerase Subunit Delta P125, Polymerase (DNA Directed) Delta 1 Catalytic Subunit (125kD), Polymerase (DNA Directed) Delta 1 Catalytic Subunit 125kDa, CDC2 Homolog (S. Cerevisiae), CDC2 Homolog
    Entrez ID:
    5424
    Related biomarkers:
    Mutation
    1year
    Dr. Starr on the Characterization of POLE/POLD1 Mutations in Colorectal Adenocarcinoma https://t.co/oIK9OWCxKB via @onclive (@NANETS1)
    POLE (DNA Polymerase Epsilon) • POLD1 (DNA Polymerase Delta 1)
    |
    POLE mutation • POLD1 mutation
    almost3years
    Wang et al. show in #colorectalcancer patients that #NTRK-positive tumours have an increased tumour mutation burden, a higher MSI frequency, and an enrichment of POLE/POLD1 mutations compared to a molecularly unselected #CRC population. #ASCO21 @ASCO @MNagasaka @oncoOuLungCA (@ntrkconnectinfo)
    Clinical
    |
    TMB (Tumor Mutational Burden) • POLE (DNA Polymerase Epsilon) • POLD1 (DNA Polymerase Delta 1) • NTRK (Neurotrophic receptor tyrosine kinase)
    |
    POLE mutation • POLD1 mutation • NTRK positive
    over3years
    #ASCO20 @ASCO Biomarkers to select patients with #prostatecancer for immune checkpoint inhibitors: MSI, MMRd, HRD, CDK12 inactivation, and POLE, POLD1 mutation. Comprehensive overview by Matthew Rettig @ucla @OncoAlert @urotoday @TiansterZhang (@neerajaiims)
    Clinical • Checkpoint inhibition
    |
    CDK12 (Cyclin dependent kinase 12) • POLD1 (DNA Polymerase Delta 1)
    |
    POLD1 mutation