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    BIOMARKER:

    PIK3CA E542

    i
    Other names: PIK3CA, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha, Phosphoinositide-3-kinase, catalytic, alpha polypeptide, Serine/threonine protein kinase PIK3CA, PtdIns-3-kinase subunit P110-alpha, PI3K-alpha, Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 KDa catalytic subunit alpha, Phosphatidylinositol 3-kinase, Catalytic, 110-KD, alpha, PI3-kinase P110 subunit alpha, PI3-kinase subunit alpha, PtdIns-3-kinase subunit alpha, PI3Kalpha, P110alpha, PI3K
    Entrez ID:
    5290
    Related biomarkers:
    Expression
    Mutation
    CNA
    Others
    2years
    Young patient with PIK3CA E542K mut/RAS WT metastatic colon cancer. Currently has good response with iri/panitumumab after FOLFOX. If he progresses, any reason to believe everolimus or alpelisib will work? Should I add low-dose aspirin? @pashtoonkasi @Dr_R_Kurzrock @GIcancerDoc (@fernandbteich)
    Clinical
    |
    PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha)
    |
    RAS wild-type • PIK3CA E542K • PIK3CA E542
    |
    5-fluorouracil • everolimus • Vectibix (panitumumab) • Piqray (alpelisib) • leucovorin calcium • aspirin
    3years
    Thoracic Oncology Community: -Woman 48yo -3 metachronic primaries: * LUAD pT1pN0M0 EIA - EGFRWt, ALK-, PD-L1-, Her2-, ROS1- * LUAD - 3rd prim. metachronous (2nd lung) pT2apN0M0 EIB - PD-L1>1%, EGFR-E709_T710> D (exon 18 - 0.1% freq.), PIK3CA-E542K, TMB- 3. Granulosa ovarian tumor (@AndresFCardonaZ)
    Clinical
    |
    EGFR (Epidermal growth factor receptor) • HER-2 (Human epidermal growth factor receptor 2) • PD-L1 (Programmed death ligand 1) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS)
    |
    PIK3CA E542K • EGFR exon 18 mutation • PIK3CA E542