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BIOMARKER:
PDGFRA exon 18 mutation
i
Other names:
Platelet Derived Growth Factor Receptor Alpha, Platelet-Derived Growth Factor Receptor Alpha Polypeptide, Alpha-Type Platelet-Derived Growth Factor Receptor, CD140 Antigen-Like Family Member A, CD140a Antigen, PDGF-R-Alpha, PDGFR-2, PDGFR2, Alpha Platelet-Derived Growth Factor Receptor, Platelet-Derived Growth Factor Alpha Receptor, PDGFR-Alpha, RHEPDGFRA, CD140A
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Entrez ID:
5156
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
PDGFRA D842V (8)
PDGFRA mutation (8)
FIP1L1-PDGFRA rearrangement (2)
PDGFRA G853D (2)
PDGFRA H845Y (2)
PDGFRA P577S (2)
PDGFRA R841K (2)
PDGFRA V658A (2)
PDGFRA rs2228230 (2)
PDGFRA D842Y (1)
PDGFRA D846Y (1)
PDGFRA DI842_843IM (1)
PDGFRA HDSN845_848P (1)
PDGFRA I843_D846delIMHD (1)
PDGFRA N659K (1)
PDGFRA N848K (1)
PDGFRA RD841_842KI (1)
PDGFRA T301T (1)
PDGFRA Y849K (1)
PDGFRA exon 12 mutation (1)
PDGFRA rearrangement (1)
PDGFR wild-type (0)
PDGFRA D842V (8)
PDGFRA mutation (8)
FIP1L1-PDGFRA rearrangement (2)
PDGFRA G853D (2)
PDGFRA H845Y (2)
PDGFRA P577S (2)
PDGFRA R841K (2)
PDGFRA V658A (2)
PDGFRA rs2228230 (2)
PDGFRA D842Y (1)
PDGFRA D846Y (1)
PDGFRA DI842_843IM (1)
PDGFRA HDSN845_848P (1)
PDGFRA I843_D846delIMHD (1)
PDGFRA N659K (1)
PDGFRA N848K (1)
PDGFRA RD841_842KI (1)
PDGFRA T301T (1)
PDGFRA Y849K (1)
PDGFRA exon 12 mutation (1)
PDGFRA rearrangement (1)
PDGFR wild-type (0)
›
Associations
(3)
News
Trials
Search handles
@schoffski
Search handles
@schoffski
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Latest
4years
According to a press release from Blueprint Med. the 476 patient Phase 3 VOYAGER trial of avapritinib vs. regorafenib in GIST did not meet the progression-free survival endpoint; the company is discontinuing development of avapritinib in GIST beyond PDGFRA exon 18 mutant GIST (@schoffski)
4 years ago
Clinical • P3 data
|
PDGFRA (Platelet Derived Growth Factor Receptor Alpha)
|
PDGFRA mutation • PDGFRA exon 18 mutation
|
Stivarga (regorafenib) • Ayvakit (avapritinib)
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