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BIOMARKER:
PDGFRA D842V
i
Other names:
Platelet Derived Growth Factor Receptor Alpha, Platelet-Derived Growth Factor Receptor Alpha Polypeptide, Alpha-Type Platelet-Derived Growth Factor Receptor, CD140 Antigen-Like Family Member A, CD140a Antigen, PDGF-R-Alpha, PDGFR-2, PDGFR2, Alpha Platelet-Derived Growth Factor Receptor, Platelet-Derived Growth Factor Alpha Receptor, PDGFR-Alpha, RHEPDGFRA, CD140A
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News alerts, weekly reports and conference planners
Entrez ID:
5156
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
›
Related tests:
AYVAKIT® CDx test
therascreen PDGFRA RGQ PCR kit
AYVAKIT® CDx test
therascreen PDGFRA RGQ PCR kit
Associations
(8)
News
Trials
Search handles
@DrCeSarcoma
@JTrentMDPhD
@PestanaRC
@VivekSubbiah
Search handles
@DrCeSarcoma
@JTrentMDPhD
@PestanaRC
@VivekSubbiah
Filter by
Latest
1year
Probably this is transformed AML from Eosinophilia. Just need to check if the NGS shows PDGFRA D842V mutation. If this mutation present , then it won’t respond to imatinib. Avapritinib is drug of choice. We had similar patient whom we transplanted in CR1. Relapsed with EM disez. (@SujayRainchwar)
1 year ago
Clinical • Next-generation sequencing
|
PDGFRA (Platelet Derived Growth Factor Receptor Alpha)
|
PDGFRA D842V • PDGFRA mutation
|
imatinib • Ayvakit (avapritinib)
2years
KEYNOTE-811 → HER-2 gastric cancer → pembro+trastuzumab+chemo KEYNOTE 590 → Esophageal SCC → Pembro+Chemo JUPITER-06 → Esophageal SCC → toripalimab+ Chemo VOYAGER → PDGFRA D842V GIST → avapritinib vs. regorafenib (@AliAlqahtaniMD)
2 years ago
HER-2 (Human epidermal growth factor receptor 2) • PDGFRA (Platelet Derived Growth Factor Receptor Alpha)
|
PDGFRA D842V
|
Keytruda (pembrolizumab) • Herceptin (trastuzumab) • Loqtorzi (toripalimab-tpzi) • Stivarga (regorafenib) • Ayvakit (avapritinib)
3years
This week @benweinbergmd highlighted “Avapritinib in unresectable or metastatic PDGFRA D842V- mutant gastrointestinal stromal tumours: Long-term efficacy and safety data from the NAVIGATOR phase I trial" @OncologyAdvance. View the full weekly list via: https://t.co/74fkdT4fhG (@RueschCenter)
3 years ago
Clinical
|
PDGFRA (Platelet Derived Growth Factor Receptor Alpha)
|
PDGFRA D842V
|
Ayvakit (avapritinib)
over3years
Next week, I’ll evaluate a patient with metastatic GIST and PDGFRA D842V mutation. Avapritinib and ripretinib are not approved in Brazil. Is there a way for compassionate access to these drugs outside the USA? @JTrentMDPhD @DrCeSarcoma @Deciphera @BlueprintMeds @VivekSubbiah (@PestanaRC)
over 3 years ago
Clinical
|
PDGFRA (Platelet Derived Growth Factor Receptor Alpha)
|
PDGFRA D842V • PDGFRA mutation
|
Ayvakit (avapritinib) • Qinlock (ripretinib)
over3years
Hay varios tipos de cáncer de estómago. Este fármaco sólo vale si son tumores del estoma gastrointestinal (GIST) con la mutación en PDGFRA D842V, que es un tipo de tumor bastante raro (@DrCeSarcoma)
over 3 years ago
PDGFRA (Platelet Derived Growth Factor Receptor Alpha)
|
PDGFRA D842V • PDGFRA mutation
over3years
Avapritinib in advanced PDGFRA D842V-mutant #GIST @sciencedirect @TheLancetOncol @schoffski @RobinL_Jones @rutkowskip1972 @WTapMD @DrCeSarcoma https://t.co/ZLS73J5rsX (@JTrentMDPhD)
over 3 years ago
PDGFRA (Platelet Derived Growth Factor Receptor Alpha)
|
PDGFRA D842V • PDGFRA mutation
|
Ayvakit (avapritinib)
over3years
Avapritinib in advanced PDGFRA D842V-mutant gastrointestinal stromal tumour (NAVIGATOR): a multicentre, open-label, phase 1 trial - ScienceDirect https://t.co/IqLLZXsm1l (@VivekSubbiah)
over 3 years ago
Clinical
|
PDGFRA (Platelet Derived Growth Factor Receptor Alpha)
|
PDGFRA D842V • PDGFRA mutation
|
Ayvakit (avapritinib)
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