PD-1 expression

$NWBO Keytruda trials for lung and prostate cancer ended today. Without combining with something like DCVax that causes tumors to increase their PD1 expression (see the DCVax trial by @VivekSubbiah et al), Keytruda may be reaching its limits. (@BIO99_BIO99)

Pilot study of bempegaldesleukin in combination with nivolumab in patients with metastatic sarcoma with very nice correlative data ✅CD8 + T cell infiltrates and PD-1 expression correlate with improved ORR. ✅Hedgehog pathway expression correlate with resistance (@VivekSubbiah)

#ASCO22 TIGIT is expressed on immune cells in #SCLC and correlates with PD-1 expression. These are the primary analyses of PFS and planned interim OS. (@StephenVLiu)

In @Cancer_Cell: Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironment. A potential distinction of Tx relevance in the immune TME of lung versus liver metastatic sites. FWIW, lactic acid is an old culprit. https://t.co/xsIefyn6lw (@Aiims1742)

Correct..prev published TMB (our work and others) has demonstrated no bearing in anal CA; 90% of all pts HPV+; PD-1 expression is also not the sole answer.. more to follow...esp. with our larger studies. #teamwork = @VanMorrisMD + @CathyEngMD @VUMC_Cancer @MDAndersonNews #ancsm (@CathyEngMD)

Pretty intriguing stuff! Using MRI radiomics to predict immuno-oncological characteristics of #HCC #HPBSCM expression of #immunotherapy targets PD-L1 at protein level and PD1, CTLA4 at mRNA expression level hepatocellular carcinoma. ⁦@MountSinaiNYC⁩ https://t.co/4OBWK0VJPy (@kmody29)