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    BIOMARKER:

    NTRK2 fusion

    i
    Other names: NTRK2, TRKB, Neurotrophic tyrosine kinase, receptor, type 2
    Entrez ID:
    4915
    Related biomarkers:
    Expression
    Mutation
    Fusion
    Others
    Related tests:
    12ms
    🔥E-learning from @DrEzraCohen on TRK fusion-positive thyroid cancers. KEY POINTS ✅#NTRK fusions = more common in paediatric vs adult #thyroid cancer ✅#NTRK2 fusions not seen ✅Different prognosis in NTRK1 vs NTRK3 fusion-positive thyroid cancer https://t.co/NMMjp4HiJc #MedEd (@PresOnc_Connect)
    NTRK1 (Neurotrophic tyrosine kinase, receptor, type 1) • NTRK3 (Neurotrophic tyrosine kinase, receptor, type 3) • NTRK2 (Neurotrophic tyrosine kinase, receptor, type 2) • NTRK (Neurotrophic receptor tyrosine kinase)
    |
    NTRK1 fusion • NTRK3 fusion • NTRK2 fusion • NTRK3 positive • NTRK fusion
    1year
    Interesting learning from @DrEzraCohen on #TRK fusion-positive thyroid cancers ✅#NTRK fusions more common in paediatric vs adult #thyroidcancer ✅#NTRK2 fusions not seen ✅Different prognosis in NTRK1 vs NTRK3 fusion-positive thyroid cancer https://t.co/6NePVisJwk #MedEd (@PresOnc_Connect)
    NTRK1 (Neurotrophic tyrosine kinase, receptor, type 1) • NTRK3 (Neurotrophic tyrosine kinase, receptor, type 3) • NTRK2 (Neurotrophic tyrosine kinase, receptor, type 2) • NTRK (Neurotrophic receptor tyrosine kinase)
    |
    NTRK1 fusion • NTRK3 fusion • NTRK2 fusion • NTRK3 positive • NTRK fusion
    over1year
    New learning from @DrEzraCohen on #TRK fusion-positive thyroid cancers. KEY POINTS -#NTRK fusions = more common in paediatric vs adult #thyroid cancer -#NTRK2 fusions not seen -Different prognosis in NTRK1 vs NTRK3 fusion-positive thyroid cancer https://t.co/W3nDR66sYB #MedEd (@ntrkconnectinfo)
    NTRK1 (Neurotrophic tyrosine kinase, receptor, type 1) • NTRK3 (Neurotrophic tyrosine kinase, receptor, type 3) • NTRK2 (Neurotrophic tyrosine kinase, receptor, type 2) • NTRK (Neurotrophic receptor tyrosine kinase)
    |
    NTRK1 fusion • NTRK3 fusion • NTRK2 fusion • NTRK3 positive • NTRK fusion
    over1year
    New learning from @DrEzraCohen on TRK fusion-positive thyroid cancers. KEY POINTS -#NTRK fusions = more common in paediatric vs adult #thyroid cancer -#NTRK2 fusions not seen -Different prognosis in NTRK1 vs NTRK3 fusion-positive thyroid cancer https://t.co/BctFnKUlAS #MedEd (@ntrkconnectinfo)
    NTRK1 (Neurotrophic tyrosine kinase, receptor, type 1) • NTRK3 (Neurotrophic tyrosine kinase, receptor, type 3) • NTRK2 (Neurotrophic tyrosine kinase, receptor, type 2) • NTRK (Neurotrophic receptor tyrosine kinase)
    |
    NTRK1 fusion • NTRK3 fusion • NTRK2 fusion • NTRK3 positive • NTRK fusion
    over1year
    Selpercatinib apprvd for RET fusion+ solid tumors 63% pts w/ clinical benefit, 2 CR and 16 PR, n=41 🔜 @OncoKB 5th tumor-agnostic @US_FDA approval (MSI-H [2017], NTRK1/2/3 fusions [2018], TMB-H [2020], BRAF V600E [2022]) https://t.co/OuLRus2uXe 👏@VivekSubbiah, @alexdrilon👏 (@CDebyaniPhD)
    Clinical • FDA event • Pan tumor
    |
    BRAF (B-raf proto-oncogene) • TMB (Tumor Mutational Burden) • MSI (Microsatellite instability) • RET (Ret Proto-Oncogene) • NTRK1 (Neurotrophic tyrosine kinase, receptor, type 1) • NTRK3 (Neurotrophic tyrosine kinase, receptor, type 3) • NTRK2 (Neurotrophic tyrosine kinase, receptor, type 2)
    |
    BRAF V600E • TMB-H • MSI-H/dMMR • BRAF V600 • NTRK1 fusion • NTRK3 fusion • NTRK2 fusion • RET fusion
    |
    Retevmo (selpercatinib)