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    over1year
    NOTCH1 mutation in chronic lymphocytic leukaemia is associated with an enhanced cell cycle G1/S transition and specific cyclin overexpression: Preclinical ground for targeted inhibition https://t.co/eK7rwedkpr #CLL #leusm (@smbenlazar)
    NOTCH1 (Notch 1)
    |
    NOTCH1 mutation
    over1year
    A) Notch1 mutation is highly acquired in clonally related DLBCL (@NickSh85)
    NOTCH1 (Notch 1)
    |
    NOTCH1 mutation
    almost2years
    Nonleukemic T/B mixed phenotype acute #Leukemia with #PHF6 and #NOTCH1 mutations👇 https://t.co/ciVyqyM53x @StanfordMed #MPAL (@davidhenrymd)
    NOTCH1 (Notch 1) • PHF6 (PHD Finger Protein 6)
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    NOTCH1 mutation • PHF6 mutation
    almost3years
    Turning clonal fitness paradigms on its head: Mutant clones in normal epithelium outcompete and eliminate esophageal micro-tumors https://t.co/mSvH578tLt & Notch1 mutation drives clonal expansion in normal esophageal epithelium but impairs tumor growth https://t.co/kcd6ZMoxyP (@Aiims1742)
    NOTCH1 (Notch 1)
    |
    NOTCH1 mutation
    almost3years
    Excited to share our latest work led by Chang-Lung Lee on radiation-induced lymphomas. A lot of studies have been done with p53 mutant or other tumor prone mice. Chang-Lung shows that Notch1 mutation is a driver in p53 wild type lymphomas after TBI. https://t.co/ZXs9hPj2Gw (@DKirschMDPhD)
    TP53 (Tumor protein P53) • NOTCH1 (Notch 1)
    |
    TP53 mutation • NOTCH1 mutation
    almost4years
    #OncoAlert Online @CCR_AACR correlation of mutations in NOTCH1/2/3 with better outcomes to checkpoint inhibitors in #NSCLC. Observed higher RR, PFS and OS when mutations present. Potential predictive and not prognostic marker. #LCSM https://t.co/wNGE9iuSzy (@StephenVLiu)
    Checkpoint inhibition
    |
    NOTCH1 (Notch 1)
    |
    NOTCH1 mutation