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    BIOMARKER:

    NECTIN4 expression

    i
    Other names: NECTIN4, Nectin Cell Adhesion Molecule 4, Nectin-4, LNIR, PRR4, Poliovirus Receptor-Related Protein 4, Poliovirus Receptor-Related 4, Ig Superfamily Receptor LNIR, PVRL4, Nectin 4, EDSS1
    Entrez ID:
    81607
    Related biomarkers:
    Expression
    over1year
    In @practiceupdate, Fox Chase's @BenMironMD shares research from a report on patterns of membranous NECTIN-4 protein expression in a cohort of paired primary and metastatic tumor samples from patients with bladder cancer. Read it here: https://t.co/CMFIvm8AXa (@FoxChaseCancer)
    Clinical • Metastases
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    NECTIN4 (Nectin Cell Adhesion Molecule 4)
    |
    NECTIN4 expression
    over1year
    We believe that membranous NECTIN4 expression is also predictive for the synergistic/ additive response of EV+Pembro. We hope the uro-oncology community will promptly test this hypothesis. We would be very happy about collaboration on this topic @Markuseckstein3 @HolzelMichael (@niklas_kluemper)
    NECTIN4 (Nectin Cell Adhesion Molecule 4)
    |
    NECTIN4 expression
    |
    Keytruda (pembrolizumab)
    2years
    I especially appreciated @sonpavde’s coda about a potential role for precision medicine with these agents, especially in earlier stage disease, owing to most UCs expressing Nectin-4 and Trop2. #GU22 (@Bladdertrio)
    NECTIN4 (Nectin Cell Adhesion Molecule 4)
    |
    NECTIN4 expression
    over2years
    Not because Nectin4 is expressed in 90% of urothelial cancer cells! (@cdanicas)
    NECTIN4 (Nectin Cell Adhesion Molecule 4)
    |
    NECTIN4 expression
    almost3years
    NECTIN4 Gene Expression in metastatic #urothelialcarcinoma-correlates with NECTIN4 protein-associated with Enfortumab Vedotin sensitivity-enriched in luminal subtype,GATA3, FOXA1,PPARG-lowest in neuroendocrine type @jonchou05 @UCSFCancer https://t.co/2lkwSDSvLf @practiceupdate (@sonpavde)
    NECTIN4 (Nectin Cell Adhesion Molecule 4) • FOXA1 (Forkhead Box A1) • PPARG (Peroxisome Proliferator Activated Receptor Gamma) • GATA3 (GATA binding protein 3)
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    NECTIN4 expression
    |
    Padcev (enfortumab vedotin-ejfv)