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    BIOMARKER:

    MYD88 L265P

    i
    Other names: MYD88, MYD88 Innate Immune Signal Transduction Adaptor, Myeloid Differentiation Primary Response Protein MyD88, Myeloid Differentiation Primary Response Gene (88), Myeloid Differentiation Primary Response 88, Mutant Myeloid Differentiation Primary Response 88, MYD88D
    Entrez ID:
    4615
    Related biomarkers:
    Expression
    Mutation
    Others
    1year
    Combining MYD88 L265P mutation detection and clonality determination on CSF cellular and cell‐free DNA improves diagnosis of primary CNS lymphoma - Bravetti - British Journal of Haematology - Wiley Online Library https://t.co/KC852Gix9T (@CwynKate)
    MYD88 (MYD88 Innate Immune Signal Transduction Adaptor)
    |
    MYD88 L265P
    over1year
    Giudetti et al • Emavusertib - IRAK4i • IRAK4 downstream of TLR • MZL lines: myd88 L265P conferred sensitivity to Emavusertib • improved sens to combos with PI3Ki / BTKi even when secondary resistance to these agents seen. #lymsm https://t.co/N7TzEupOkd (@graham74GC)
    MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) • IRAK4 (Interleukin 1 Receptor Associated Kinase 4)
    |
    MYD88 L265P
    |
    emavusertib (CA-4948)
    over2years
    Heme Board Review - Bing Neel Syndrome! Rare manifestation of Waldenström’s macroglobulinemia/LPL Infiltration of the CNS by lymphoplasmacytic cells Usually at disease relapse but can occur at presentation CSF cytology = flow CD5-/CD10- MYD88 L265P+ Rx = HDMTX, ibrutinib (@AaronGoodman33)
    Review
    |
    MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) • CD5 (CD5 Molecule) • MME (Membrane Metalloendopeptidase)
    |
    MYD88 L265P
    |
    Imbruvica (ibrutinib)
    over2years
    Morning Board Review - Bing Neel Syndrome! Rare manifestation of Waldenström’s macroglobulinemia/LPL Infiltration of the CNS by lymphoplasmacytic cells Usually at disease relapse but can occur at presentation CSF cytology = flow CD5-/CD10- MYD88 L265P+ Rx = HDMTX, ibrutinib (@AaronGoodman33)
    Review
    |
    MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) • CD5 (CD5 Molecule) • MME (Membrane Metalloendopeptidase)
    |
    MYD88 L265P
    |
    Imbruvica (ibrutinib)
    over2years
    Waldenstorm macroglobulinemia #mmsm ➡️Lymphoid (+ve B cell markers, CD20)/plasmacytoid (+ve CD138)👇 ➡️Mutations: 🩸MYD88:L265P,most common, helps in diff from MM, mutated=good prog 🩸CXCR4:less common, mutated=worse prog ➡️excellent review @MorieGertz: https://t.co/UmDrQj69wt (@HadidiSamer)
    Review
    |
    CD20 (Membrane Spanning 4-Domains A1) • MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) • CXCR4 (Chemokine (C-X-C motif) receptor 4) • SDC1 (Syndecan 1)
    |
    MYD88 L265P
    3years
    MYD88 L265P elicits mutation-specific ubiquitination to drive NF-κB activation and lymphomagenesis https://t.co/80V08J5MFl (@BloodJournal)
    MYD88 (MYD88 Innate Immune Signal Transduction Adaptor)
    |
    MYD88 L265P