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BIOMARKER:
MYD88 L265P
i
Other names:
MYD88, MYD88 Innate Immune Signal Transduction Adaptor, Myeloid Differentiation Primary Response Protein MyD88, Myeloid Differentiation Primary Response Gene (88), Myeloid Differentiation Primary Response 88, Mutant Myeloid Differentiation Primary Response 88, MYD88D
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News alerts, weekly reports and conference planners
Entrez ID:
4615
Related biomarkers:
Expression
Mutation
Others
‹
›
Associations
(13)
News
Trials
Search handles
@AaronGoodman33
@CwynKate
@HadidiSamer
@graham74GC
Search handles
@AaronGoodman33
@CwynKate
@HadidiSamer
@graham74GC
Filter by
Latest
1year
Combining MYD88 L265P mutation detection and clonality determination on CSF cellular and cell‐free DNA improves diagnosis of primary CNS lymphoma - Bravetti - British Journal of Haematology - Wiley Online Library https://t.co/KC852Gix9T (@CwynKate)
1 year ago
MYD88 (MYD88 Innate Immune Signal Transduction Adaptor)
|
MYD88 L265P
1year
Giudetti et al • Emavusertib - IRAK4i • IRAK4 downstream of TLR • MZL lines: myd88 L265P conferred sensitivity to Emavusertib • improved sens to combos with PI3Ki / BTKi even when secondary resistance to these agents seen. #lymsm https://t.co/N7TzEupOkd (@graham74GC)
1 year ago
MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) • IRAK4 (Interleukin 1 Receptor Associated Kinase 4)
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MYD88 L265P
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emavusertib (CA-4948)
2years
Heme Board Review - Bing Neel Syndrome! Rare manifestation of Waldenström’s macroglobulinemia/LPL Infiltration of the CNS by lymphoplasmacytic cells Usually at disease relapse but can occur at presentation CSF cytology = flow CD5-/CD10- MYD88 L265P+ Rx = HDMTX, ibrutinib (@AaronGoodman33)
2 years ago
Review
|
MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) • CD5 (CD5 Molecule) • MME (Membrane Metalloendopeptidase)
|
MYD88 L265P
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Imbruvica (ibrutinib)
over2years
Morning Board Review - Bing Neel Syndrome! Rare manifestation of Waldenström’s macroglobulinemia/LPL Infiltration of the CNS by lymphoplasmacytic cells Usually at disease relapse but can occur at presentation CSF cytology = flow CD5-/CD10- MYD88 L265P+ Rx = HDMTX, ibrutinib (@AaronGoodman33)
over 2 years ago
Review
|
MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) • CD5 (CD5 Molecule) • MME (Membrane Metalloendopeptidase)
|
MYD88 L265P
|
Imbruvica (ibrutinib)
over2years
Waldenstorm macroglobulinemia #mmsm ➡️Lymphoid (+ve B cell markers, CD20)/plasmacytoid (+ve CD138)👇 ➡️Mutations: 🩸MYD88:L265P,most common, helps in diff from MM, mutated=good prog 🩸CXCR4:less common, mutated=worse prog ➡️excellent review @MorieGertz: https://t.co/UmDrQj69wt (@HadidiSamer)
over 2 years ago
Review
|
CD20 (Membrane Spanning 4-Domains A1) • MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) • CXCR4 (Chemokine (C-X-C motif) receptor 4) • SDC1 (Syndecan 1)
|
MYD88 L265P
almost3years
MYD88 L265P elicits mutation-specific ubiquitination to drive NF-κB activation and lymphomagenesis https://t.co/80V08J5MFl (@BloodJournal)
almost 3 years ago
MYD88 (MYD88 Innate Immune Signal Transduction Adaptor)
|
MYD88 L265P
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