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BIOMARKER:
MYC rearrangement
i
Other names:
MYC, bHLHe39, c-Myc, MYCC, V-myc avian myelocytomatosis viral oncogene homolog
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Entrez ID:
4609
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
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Associations
(7)
News
Trials
Search handles
@AaronGoodman33
@MediHumdani
Search handles
@AaronGoodman33
@MediHumdani
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Latest
over1year
How would you treat DLBCL edition! A 50 yo patient presents with a left parotid mass. Biopsy is consistent with DLBCL, germinal center subtype. PET/CT is unrevealing other than left parotid mass. ECOG = 0 LDH = normal FISH panel = MYC and BCL2 rearrangements! (@AaronGoodman33)
over 1 year ago
Clinical • Biopsy
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BCL2 (B-cell CLL/lymphoma 2)
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MYC rearrangement • BCL2 rearrangement
over1year
DLBCL- high grade B-cell lymphoma with MYC and BCL2 rearrangements .. R-EPOCH? 👀 (@Itsinmyblood92)
over 1 year ago
BCL2 (B-cell CLL/lymphoma 2)
|
MYC rearrangement • BCL2 rearrangement
over1year
- Diffuse large B-cell lymphoma/high-grade B-cell lymphoma with MYC and BCL2 rearrangements (DLBCL/HGBL-MYC/BCL2) - DA EPOCH-R (@ghous_ghulam)
over 1 year ago
MYC (V-myc avian myelocytomatosis viral oncogene homolog) • BCL2 (B-cell CLL/lymphoma 2)
|
MYC rearrangement • BCL2 rearrangement
over1year
DLBCL/HGBL with MYC and BCL 2 rearrangement. Rx R-DA-EPOCH, not sure about the evidence in support of using R-DA-EPOCH or R-CODOX-M/IVAC. (@drsahilbhagat13)
over 1 year ago
BCL2 (B-cell CLL/lymphoma 2)
|
MYC rearrangement
over1year
Paging haematologists @tobyeyre82 @graham74GC What classification system will be you using and how would you treat a high grade B-cell lymphoma with MYC and BCL6 rearrangements? (@DrMarkOng)
over 1 year ago
BCL6 (B-cell CLL/lymphoma 6)
|
MYC rearrangement + BCL6 rearrangement • MYC rearrangement • BCL6 rearrangement
over1year
When I use DA-R-EPOCH over RCHOP in DLBCL? 1. Double expressor = No 2. High IPI = No 3. Testicular = No 4. Many extra nodal sites = No 5. MYC rearrangement = No 6. MYC and BCL2 copy # gains = No 7. MYC+BCL2 translocations (2-Hit) = I don’t know 8. HIV associated = I don't know (@AaronGoodman33)
over 1 year ago
MYC (V-myc avian myelocytomatosis viral oncogene homolog) • BCL2 (B-cell CLL/lymphoma 2)
|
MYC rearrangement • BCL2 translocation
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Rituxan (rituximab)
almost2years
Double Hit (DH) vs Expressor DLBCL (DE) DE = IHC MYC+(>40%), BCL2+(>50%) ABC>GCB Bad Rx = RCHOP DH = FISH MYC+BCL2 and/or BCL6 rearrangement GCB>ABC Very bad (esp MYC+IG partner) Rx = DA-EPOCH-R? DH gene sig = RNA 50% negative for MYC+BCL2 rearrangement Very bad Rx = ??? (@AaronGoodman33)
almost 2 years ago
MYC (V-myc avian myelocytomatosis viral oncogene homolog) • BCL2 (B-cell CLL/lymphoma 2) • BCL6 (B-cell CLL/lymphoma 6)
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MYC rearrangement + BCL2 rearrangement • MYC rearrangement • BCL6 rearrangement • BCL2 rearrangement
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Rituxan (rituximab)
over2years
Lymphoma Question! 55 yo with abdominal pain. PET/CT gastric mass and nothing else. EGD with 6 cm gastric mass Biopsy DLBCL, NOS, germinal center FISH with MYC-IgH + BCL2-IGH rearrangements Stage IE IPI = 0 Your treatment rec? @ASkarbnik @dgermain21 Or comment answer! (@AaronGoodman33)
over 2 years ago
BCL2 (B-cell CLL/lymphoma 2)
|
MYC rearrangement • BCL2 rearrangement
over2years
56 year old male with DLBCL in CR2 after RICE salvage. PET negative. no c-myc rearrangement. Fails HPC mobilization with G-CSF/ mozobil (PB CD34+ <1/uL). Data-free zone, no MDS. What would people do? #lymSM #bmtSM #mozobil #apheresis (@MediHumdani)
over 2 years ago
MYC (V-myc avian myelocytomatosis viral oncogene homolog) • CD34 (CD34 molecule)
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MYC rearrangement
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plerixafor
over2years
Double Hit (DH) vs Expressor DLBCL (DE) DE = IHC MYC+(>40%), BCL2+(>50%) ABC>GCB Bad Rx = RCHOP DH = FISH MYC+BCL2 and/or BCL6 rearrangement GCB>ABC Very bad (esp MYC+IG) Rx = RCHOP or DA-EPOCH-R? DH gene sig = RNA 50% negative for MYC+BCL2 rearrangement Very bad Rx = ??? (@AaronGoodman33)
over 2 years ago
MYC (V-myc avian myelocytomatosis viral oncogene homolog) • BCL2 (B-cell CLL/lymphoma 2) • BCL6 (B-cell CLL/lymphoma 6)
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MYC rearrangement + BCL2 rearrangement • MYC rearrangement • BCL6 rearrangement • BCL2 rearrangement
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Rituxan (rituximab)
over2years
Curious how people approach this? (I struggle with these) Newly diagnosed DLBCL-NOS (sole c-myc rearrangement; or ignore that part), surgically rendered no evidence of disease. PET negative / Marrow negative (if done). Perfectly healthy #lymphoma #lymsm #medED (@MediHumdani)
over 2 years ago
Clinical
|
MYC (V-myc avian myelocytomatosis viral oncogene homolog)
|
MYC rearrangement
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