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    BIOMARKER:

    MYC rearrangement + BCL2 rearrangement

    i
    Other names: MYC, bHLHe39, c-Myc, MYCC, V-myc avian myelocytomatosis viral oncogene homolog, BCL2, Bcl-2, PPP1R50, B-cell CLL/lymphoma 2
    Entrez ID:
    4609; 596
    Related biomarkers:
    Expression
    Mutation
    CNA
    Fusion
    Others
    almost2years
    Double Hit (DH) vs Expressor DLBCL (DE) DE = IHC MYC+(>40%), BCL2+(>50%) ABC>GCB Bad Rx = RCHOP DH = FISH MYC+BCL2 and/or BCL6 rearrangement GCB>ABC Very bad (esp MYC+IG partner) Rx = DA-EPOCH-R? DH gene sig = RNA 50% negative for MYC+BCL2 rearrangement Very bad Rx = ??? (@AaronGoodman33)
    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • BCL2 (B-cell CLL/lymphoma 2) • BCL6 (B-cell CLL/lymphoma 6)
    |
    MYC rearrangement + BCL2 rearrangement • MYC rearrangement • BCL6 rearrangement • BCL2 rearrangement
    |
    Rituxan (rituximab)
    over2years
    Double Hit (DH) vs Expressor DLBCL (DE) DE = IHC MYC+(>40%), BCL2+(>50%) ABC>GCB Bad Rx = RCHOP DH = FISH MYC+BCL2 and/or BCL6 rearrangement GCB>ABC Very bad (esp MYC+IG) Rx = RCHOP or DA-EPOCH-R? DH gene sig = RNA 50% negative for MYC+BCL2 rearrangement Very bad Rx = ??? (@AaronGoodman33)
    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • BCL2 (B-cell CLL/lymphoma 2) • BCL6 (B-cell CLL/lymphoma 6)
    |
    MYC rearrangement + BCL2 rearrangement • MYC rearrangement • BCL6 rearrangement • BCL2 rearrangement
    |
    Rituxan (rituximab)