MYC overexpression

.@bvantine1, of @WUSTLmed, discusses the rationale for the phase 1 study of KB-0742 in MYC-amplified or -overexpressed R/R solid tumors, and patient characteristics that may signal their eligibility for participation in this trial. #Oncology https://t.co/FJVRjTvp6n (@OncLive)

Rapid, jerking movements of both eyes with infraorbital ecchymoses bilaterally, firm mass anterior to the left flank -- neuroblastoma, elevated catecholamines, N-myc overexpression (@AyasunMDPhD)

As @AaronGoodman33 correctly pointed out, MYC in this case is not overexpressed. While not entirely sensitive, usually MYC-r cases show overexpression of MYC by IHC, so that’s against double hit lymphoma. Left pic our case, right pic example of MYC in DHL from #expertpath (@sanamloghavi)

Joyce Lee @goga_lab -MYC is overexpressed in TNBC -MYC suppresses T-Cells in breast cancer -MYC tumors required additional therapies to improve response to anti PD1/PDL1. #SABCS20 #bcsm (@jesusanampa)

#ASH20 Juxtaposing the talks of @etenhacken and @BKnisbacher was an excellent choice. Curious whether Mga mutation is necessary for U-CLL transformation whereas transforming M-CLL follows a different pathway towards Myc overexpression. (@joshuaafein)