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BIOMARKER:
MYC expression
i
Other names:
MYC, bHLHe39, c-Myc, MYCC, V-myc avian myelocytomatosis viral oncogene homolog
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Entrez ID:
4609
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
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Associations
(9)
News
Trials
Search handles
@AaronGoodman33
@AyasunMDPhD
@Fer_martinmoro
@graham74GC
@jesusanampa
@majorajay
Search handles
@AaronGoodman33
@AyasunMDPhD
@Fer_martinmoro
@graham74GC
@jesusanampa
@majorajay
Filter by
Latest
10ms
Late-breaking #17ICML first GWAS on 800 Burkitt cases in East Africa: - 21q22.12 locus identified in Burkitt cases, part of haplotype common in Africa - this locus overlaps with RUNX1 enhancer, with identification of a novel BL transcript linked to MYC expression #lymsm #GWAS (@majorajay)
10 months ago
Clinical • Late-breaking abstract
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MYC (V-myc avian myelocytomatosis viral oncogene homolog) • RUNX1 (RUNX Family Transcription Factor 1)
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MYC expression
10ms
Hot off the press, our paper on interactions between COO and MYC/BCL2 expression in patients with relapsed LBCL undergoing ASCT. Thankful to my mentors at @MDAndersonNews Dr. Issa Khouri @Transplant_Doc @RichardChamplin and others #bmtsm #lymphoma #lymsm https://t.co/zoqRFsEd3G (@Taha_CancerDoc)
10 months ago
Clinical • IO biomarker
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MYC (V-myc avian myelocytomatosis viral oncogene homolog) • BCL2 (B-cell CLL/lymphoma 2)
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BCL2 expression • MYC expression
12ms
Hopefully these findings will re-invigorate discussion on how MYC, BCL2 and BCL6 expression (not translocation) relate to poor risk lymphoma, and how to overcome this with novel agents. Thanks @AshAlizadeh for all your suggestions over the years. (@adj_23)
12 months ago
IO biomarker
|
MYC (V-myc avian myelocytomatosis viral oncogene homolog) • BCL2 (B-cell CLL/lymphoma 2) • BCL6 (B-cell CLL/lymphoma 6)
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MYC expression
over1year
Mantle cell lymphoma, Blastoid varient with MYC expression Flow pattern: CD 20 strong + CD 5 + CD 10 - CD 23 +/- CD 200 - (@Manea__Q1)
over 1 year ago
MYC (V-myc avian myelocytomatosis viral oncogene homolog) • CD20 (Membrane Spanning 4-Domains A1) • CD200 (CD200 Molecule) • FCER2 (Fc Fragment Of IgE Receptor II)
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MYC expression
over1year
Blastic mantle cell lymphoma with MYC and BCL6 expression (@documangp)
over 1 year ago
MYC (V-myc avian myelocytomatosis viral oncogene homolog) • BCL6 (B-cell CLL/lymphoma 6)
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MYC expression
over1year
Double expression of MYC/BCL2 in PCNSL is related with worse PFS (not OS), less relevant if MATRIx + auto-SCT as frontline #lymphoma #ASH22 (@Fer_martinmoro)
over 1 year ago
IO biomarker
|
MYC (V-myc avian myelocytomatosis viral oncogene homolog) • BCL2 (B-cell CLL/lymphoma 2)
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BCL2 expression • MYC expression • MYC expression + BCL2 expression
over1year
Multicentre UK study showing double Myc / Bcl2 expressor primary CNS lymphoma associated with worse PFS (trend to OS) even in MATRix treated patients. Congrats to @Jessica_Okosun and her team. #ASH22 #lymsm (@graham74GC)
over 1 year ago
Clinical
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MYC (V-myc avian myelocytomatosis viral oncogene homolog) • BCL2 (B-cell CLL/lymphoma 2)
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BCL2 expression • MYC expression
over1year
Rapid, jerking movements of both eyes with infraorbital ecchymoses bilaterally, firm mass anterior to the left flank -- neuroblastoma, elevated catecholamines, N-myc overexpression (@AyasunMDPhD)
over 1 year ago
MYC (V-myc avian myelocytomatosis viral oncogene homolog) • MYCN (MYCN Proto-Oncogene BHLH Transcription Factor)
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MYC overexpression • MYC expression
over1year
Preprint from @SearsRosie @OHSUKnight on a genetically engineered model of triple negative breast cancer (TNBC), expressing amplified oncogenic Myc combined with PTEN deletion. There’s a ton of profiling data in here reinforcing underlying heterogeneity. https://t.co/gNuFoUmRYB (@Aiims1742)
over 1 year ago
Preprint
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PTEN (Phosphatase and tensin homolog)
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PTEN deletion • MYC expression
over1year
Oncology Board Review A 65 year old with HTN is diagnosed with stage IV (marrow involvement) DLBCL, double expresser (MYC+, BCL2+). IPI = 3. ECOG = 1. What's the most apprioeate treatment regimen? (ASCT = autologous stem cell transplantation) (@AaronGoodman33)
over 1 year ago
Review
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MYC (V-myc avian myelocytomatosis viral oncogene homolog) • BCL2 (B-cell CLL/lymphoma 2)
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BCL2 expression • MYC expression
over1year
#DLBCL News: @gilles_salles, MD from @MSKCancerCenter discusses #MYC and #BCL2 Expression Impact Outcomes Post #FrontlineTreatment With #PV in DLBCL || For more of the top and trending #DLBCL videos visit: https://t.co/QCpxfDsNKd #medtwitter #hematology #research #onctwitter (@AggregoOncology)
over 1 year ago
IO biomarker
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MYC (V-myc avian myelocytomatosis viral oncogene homolog) • BCL2 (B-cell CLL/lymphoma 2)
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BCL2 expression • MYC expression
over1year
TNBCs with elevated MYC expression are resistant to immune checkpoint inhibitor therapy. This immune evasion is reversible and druggable, and when strategically targeted, may improve outcomes for patients treated with immune checkpoint inhibitors. #BCSM (@jesusanampa)
over 1 year ago
Clinical • Checkpoint inhibition • IO biomarker
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MYC (V-myc avian myelocytomatosis viral oncogene homolog)
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MYC expression
2years
As @AaronGoodman33 correctly pointed out, MYC in this case is not overexpressed. While not entirely sensitive, usually MYC-r cases show overexpression of MYC by IHC, so that’s against double hit lymphoma. Left pic our case, right pic example of MYC in DHL from #expertpath (@sanamloghavi)
2 years ago
Clinical
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MYC (V-myc avian myelocytomatosis viral oncogene homolog)
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MYC overexpression • MYC expression
over2years
Led by Dr. @NoopurRajeMD, scientists at @MGHCancerCenter and @harvardmed created NCOR2 knockout human #myeloma cell lines and demonstrated that NCOR2 knockout led to high MYC expression. 🩸 #OpenAccess in @BloodCancerJnl 📑 https://t.co/lZVxVmvqtZ (@Hema_News)
over 2 years ago
MYC (V-myc avian myelocytomatosis viral oncogene homolog) • NCOR2 (Nuclear Receptor Corepressor 2)
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MYC expression
over2years
Lymphoma Poll 70 year old with stage IV DLBCL. Expresses MYC and BCL2. Not double hit. Involvement of numerous extra-nodal sites including kidneys. LDH is elevated. Renal function normal. ECOG 2. Do you recommend CNS prophylaxis? @WomenInLymphoma (@AaronGoodman33)
over 2 years ago
MYC (V-myc avian myelocytomatosis viral oncogene homolog) • BCL2 (B-cell CLL/lymphoma 2)
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BCL2 expression • MYC expression
over2years
Weekend preprint from Prof @TannishthaReya @UCSDHealth Tracing tumor evolution & subtype specification in #PancreaticCancer https://t.co/IB4YSS30S1 Targeting oncogenic Myc to Msi2-expressing ductal cells resulting in tumors with variable histologies from a common progenitor pool (@Aiims1742)
over 2 years ago
MYC (V-myc avian myelocytomatosis viral oncogene homolog) • MSI2 (Musashi RNA Binding Protein 2)
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MYC expression
over3years
Joyce Lee @goga_lab -MYC is overexpressed in TNBC -MYC suppresses T-Cells in breast cancer -MYC tumors required additional therapies to improve response to anti PD1/PDL1. #SABCS20 #bcsm (@jesusanampa)
over 3 years ago
MYC (V-myc avian myelocytomatosis viral oncogene homolog)
|
MYC overexpression • MYC expression
over3years
#ASH20 Juxtaposing the talks of @etenhacken and @BKnisbacher was an excellent choice. Curious whether Mga mutation is necessary for U-CLL transformation whereas transforming M-CLL follows a different pathway towards Myc overexpression. (@joshuaafein)
over 3 years ago
MYC (V-myc avian myelocytomatosis viral oncogene homolog)
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MYC overexpression • MYC expression
over3years
9/ We dedicate the paper to Adi Gazdar, longtime faculty member @UTSWNews, who passed away in December, 2018. Adi was a giant in the field of small cell lung cancer, and made the original observation that cells from chemoresistant tumors tend to express MYC proteins. -RJD (@RJDLab)
over 3 years ago
MYC (V-myc avian myelocytomatosis viral oncogene homolog)
|
MYC expression
over3years
4/ Fang's new work has two major findings. First, in small cell lung cancer, the long-known shift towards enhanced MYC expression that accompanies acquired chemoresistance renders these intractable tumors SENSITIVE to IMPDH inhibitors. -RJD (@RJDLab)
over 3 years ago
MYC (V-myc avian myelocytomatosis viral oncogene homolog)
|
MYC expression
over3years
2/ In 2018, Fang reported that in some small cell lung cancers in mice, high MYC expression results in an actionable dependence on inosine monophosphate dehydrogenase (IMPDH) in the GTP synthesis pathway. -RJD https://t.co/tD5JljgdE1 (@RJDLab)
over 3 years ago
MYC (V-myc avian myelocytomatosis viral oncogene homolog)
|
MYC expression
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