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BIOMARKER:
MYC amplification
i
Other names:
MYC, bHLHe39, c-Myc, MYCC, V-myc avian myelocytomatosis viral oncogene homolog
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Entrez ID:
4609
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
BCL2 rearrangement + MYC amplification (2)
HR positive + MYC amplification (2)
MYC amplification + ALK F1174L (2)
MYC expression + MYC rearrangement (2)
MYC overexpression + IDH1 mutation (2)
MYC overexpression + IDH2 mutation (2)
MYC rearrangement + LDH elevation (2)
ALK fusion + MYC amplification + CCND1 deletion + FGFR3 deletion (1)
ALK positive + MYC amplification + CCND1 deletion (1)
EGFR T790M + MYC amplification (1)
HER-2 positive + MYC amplification (1)
HR positive + MYC mutation (1)
IDH1 mutation + MYC amplification + MAPRE1 overexpression (1)
IDH2 mutation + MYC amplification + MAPRE1 overexpression (1)
KIF5B-RET fusion + TP53 H193R + MYC amplification (1)
MYC amplification + BCL2 amplification + TNFRSF8 expression (1)
MYC mutation + ER positive (1)
miR-17-HG deletion + MYC positive (1)
BCL2 rearrangement + MYC amplification (2)
HR positive + MYC amplification (2)
MYC amplification + ALK F1174L (2)
MYC expression + MYC rearrangement (2)
MYC overexpression + IDH1 mutation (2)
MYC overexpression + IDH2 mutation (2)
MYC rearrangement + LDH elevation (2)
ALK fusion + MYC amplification + CCND1 deletion + FGFR3 deletion (1)
ALK positive + MYC amplification + CCND1 deletion (1)
EGFR T790M + MYC amplification (1)
HER-2 positive + MYC amplification (1)
HR positive + MYC mutation (1)
IDH1 mutation + MYC amplification + MAPRE1 overexpression (1)
IDH2 mutation + MYC amplification + MAPRE1 overexpression (1)
KIF5B-RET fusion + TP53 H193R + MYC amplification (1)
MYC amplification + BCL2 amplification + TNFRSF8 expression (1)
MYC mutation + ER positive (1)
miR-17-HG deletion + MYC positive (1)
›
Associations
(29)
News
Trials
Search handles
@VivekSubbiah
@jsoriamd
Search handles
@VivekSubbiah
@jsoriamd
Filter by
Latest
1year
Thomas Cyberski, medical student @UChicagoMed presents HNSCC patient data showing MYC amplification after chemotherapy and immunotherapy in a poster session at @AACR #AACR23. @AriRosenbergMD @EIzumchenko @UCCancerCenter (@UCCancerCenter)
1 year ago
Clinical
|
MYC (V-myc avian myelocytomatosis viral oncogene homolog)
|
MYC amplification
1year
Clinical Targeted Next-Generation Panel Sequencing Reveals MYC Amplification Is a Poor Prognostic Factor in Osteosarcoma | JCO Precision Oncology https://t.co/eWd6aIZaAr (@VivekSubbiah)
1 year ago
Clinical
|
MYC (V-myc avian myelocytomatosis viral oncogene homolog)
|
MYC amplification
1year
SCLC is an aggressive tumor. #MYC amplification is a driver of #SCLC heterogeneity. Extra-chromosomal DNAs bring to proximity enhancers & oncogenes, creating transcription-amplifying units, driving high MYC gene dosage. This can be seen in #liquidbiopsies https://t.co/dHKke78kzO (@jsoriamd)
1 year ago
Liquid biopsy • Biopsy
|
MYC (V-myc avian myelocytomatosis viral oncogene homolog)
|
MYC amplification
2years
Little is known about tumor-related factors that influence response to #talazoparib in #BreastCancer. Retrospective analysis by Blum et al shows that MYC amplification is associated with shorter overall survival among certain subgroups. https://t.co/qp8JqCBQXn @hoperugo (@CCR_AACR)
2 years ago
Retrospective data
|
MYC (V-myc avian myelocytomatosis viral oncogene homolog)
|
MYC amplification
|
Talzenna (talazoparib)
over2years
Final one on this 🧵: Genomic landscape of human adenosquamous #PancreaticCancer from the same @SU2Cscience @lustgartenfdn team published previously. Note lower frequency of KRAS mutations, Myc amplification in 42%, & unique epigenomic signatures. https://t.co/L5vjvcibR6 (@Aiims1742)
over 2 years ago
KRAS (KRAS proto-oncogene GTPase) • MYC (V-myc avian myelocytomatosis viral oncogene homolog)
|
KRAS mutation • MYC amplification
almost4years
secondary angiosarcoma. cmyc amplification #vasansplz (@vaskannan)
almost 4 years ago
MYC (V-myc avian myelocytomatosis viral oncogene homolog)
|
MYC amplification
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