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DRUG CLASS:
mTORC1 inhibitor
DRUG CLASS:
mTORC1 inhibitor
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News alerts, weekly reports and conference planners
Related drugs:
‹
PF-05212384 (31)
CB-228 (29)
nanoparticle albumin-bound rapamycin (10)
MTI-31 (4)
RapaLink-1 (3)
AVTX-006 (2)
SBI-756 (2)
RMC-5552 (1)
SBI-726 (1)
ATG-008 (1)
WYE-125132 (0)
XP-105 (0)
PF-05212384 (31)
CB-228 (29)
nanoparticle albumin-bound rapamycin (10)
MTI-31 (4)
RapaLink-1 (3)
AVTX-006 (2)
SBI-756 (2)
RMC-5552 (1)
SBI-726 (1)
ATG-008 (1)
WYE-125132 (0)
XP-105 (0)
›
Associations
(87)
News
Trials
Search handles
@AndresFCardonaZ
@doctorpemm
Search handles
@AndresFCardonaZ
@doctorpemm
Filter by
Latest
9ms
Gedatolisib + palbociclib & letrozole produced durable responses w/ comparable safety to that observed w/ palbociclib & letrozole alone in treatment-naïve patients withER-positive, HER2-negative advanced breast cancer @hoperugo @UCSFCancer #bcsm https://t.co/Hpc5ZFF5GJ (@OncLive)
9 months ago
Clinical • Metastases
|
HER-2 (Human epidermal growth factor receptor 2)
|
HER-2 negative
|
Ibrance (palbociclib) • letrozole • gedatolisib (PF-05212384)
9ms
Gedatolisib + palbociclib & letrozole produced durable responses w/ comparable safety to that observed w/ palbociclib & letrozole alone in treatment-naïve patients withER-positive, HER2-negative advanced breast cancer @hoperugo @UCSFCancer #bcsm https://t.co/D5Xk9qw1X0 (@OncLive)
9 months ago
Clinical • Metastases
|
HER-2 (Human epidermal growth factor receptor 2)
|
HER-2 negative
|
Ibrance (palbociclib) • letrozole • gedatolisib (PF-05212384)
10ms
Gedatolisib Triplet Shows Early Efficacy in Previously Untreated ER+/HER2– Breast Cancer @hoperugo @UCSFCancer #bcsm https://t.co/WeZVEnULVD (@OncLive)
10 months ago
Clinical
|
HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor)
|
gedatolisib (PF-05212384)
12ms
Targeting NFE2L2/KEAP1 Mutations in Advanced NSCLC With the TORC1/2 Inhibitor TAK-228 https://t.co/Y5n7ni3SOj (@AndresFCardonaZ)
12 months ago
Metastases
|
KEAP1 (Kelch Like ECH Associated Protein 1) • NFE2L2 (Nuclear Factor, Erythroid 2 Like 2)
|
KEAP1 mutation • NFE2L2 mutation
|
sapanisertib (CB-228)
1year
Investigators Unpack Role of Nab-Sirolimus for Solid Tumors With TSC1/2 Mutations @schulte_md @AgulnikMd @ucsfhealth @cityofhope #scmsm #oncology https://t.co/uIs7mnKbiz (@OncLiveSOSS)
1 year ago
TSC1 (TSC complex subunit 1)
|
TSC1 mutation
|
Fyarro (nanoparticle albumin-bound rapamycin)
over3years
Catching up on last night’s #SABCS20 spotlight. Thanks to the shout out from @curijoey showcasing @DSudhanPhD’s work on mTORC1-mediated neratinib resistance in #HER2-mutant tumors. Most of these models were *not* HER2 amp, but we saw similar results in a PDX that was HER2amp+mut (@AriellaHanker)
over 3 years ago
HER-2 (Human epidermal growth factor receptor 2)
|
Nerlynx (neratinib)
over3years
#ASH20 Excellent presentation Dr Ilaria Marina Michelozzi. Enhanced functionality of low-affinity #CD19 CAR-T cells assoc w/ activation priming & polyfunctional #cytokine phenotype #TcellRx #ImmunoOnc #leusm #lymsm | #mTORC1 #p38MAPK | #ASHKudos @ASH_hematology (@doctorpemm)
over 3 years ago
CAR T-Cell Therapy
|
CD19 (CD19 Molecule)
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