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BIOMARKER:
MCL1 expression
i
Other names:
MCL1, MCL1 Apoptosis Regulator BCL2 Family Member, Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1, Myeloid Cell Leukemia Sequence 1 (BCL2-Related), MCL1 BCL2 Family Apoptosis Regulator, Bcl-2-Related Protein EAT/Mcl1, Myeloid Cell Leukemia 1, Bcl-2-Like Protein 3, Bcl2-L-3, Mcl1/EAT, BCL2L3, BCL2 Family Apoptosis Regulator, Myeloid Cell Leukemia ES, MCL1-ES, MCL1L, MCL1S, Mcl-1, EAT, TM
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Entrez ID:
4170
Related biomarkers:
Expression
Mutation
CNA
Others
‹
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Associations
(6)
News
Trials
Search handles
@Dr_Ivanoncologo
@hemedoc
@michaelwangmd
Search handles
@Dr_Ivanoncologo
@hemedoc
@michaelwangmd
Filter by
Latest
over1year
#ASH22 #leusm Renders: GPR56 expression helps identify LSC. Mcl-1 expressed in differentiating cells while BCL2 more exclusively expressed in LSC of Ven responders, and thus BCL2:MCL-1 (assessed by MACS-Score) in LSC may be a biomarker to predict response. (@hemedoc)
over 1 year ago
IO biomarker
|
BCL2 (B-cell CLL/lymphoma 2) • MCL1 (Myeloid cell leukemia 1) • ADGRG1 (Adhesion G Protein-Coupled Receptor G1)
|
BCL2 expression • MCL1 expression
2years
In this study by Quentmeier from Germany, anaplastic large cell lymphoma & primary effusion lymphoma, stood out by high expression of MCL1 & low expression of BCL2. The MCL1 inhibitor AZD-5991 induced apoptosis in cell lines in both lymphomas. https://t.co/AQ0NOdIgVz (@michaelwangmd)
2 years ago
IO biomarker
|
BCL2 (B-cell CLL/lymphoma 2)
|
BCL2 expression • MCL1 expression
|
AZD5991
over2years
💡The #results of this #study report that #metformin downregulates the #expression of anti-apoptotic proteins Mcl-1 and Bcl-xl by inhibiting protein production, and shows a synergistic anti-tumor effect with ABT-199 in acute myeloid #leukemia Congratulations to all the authors (@Dr_Ivanoncologo)
over 2 years ago
MCL1 (Myeloid cell leukemia 1) • BCL2L1 (BCL2-like 1)
|
MCL1 expression
|
Venclexta (venetoclax) • metformin
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