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CANCER:
Mast Cell Leukemia
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Associations
(5)
News
Trials
Search handles
@TalhaBadarMD
@schoffski
@smbenlazar
Search handles
@TalhaBadarMD
@schoffski
@smbenlazar
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Latest
1year
Aggressive mast cell leukemia/sarcoma with CD4 expression and hemophagocytosis https://t.co/lmPiYbbYCE (@smbenlazar)
1 year ago
CD4 (CD4 Molecule)
|
CD4 expression
over1year
91 yrs old lady with ECOG 2, dx with mast cell leukemia on work up of cytopenia: Hb 10.7, Plt 166, ANC 1.4. No extra medullary involvement. Asymptomatic. Atypical KITm p.A502_Y503 (not D816V). NGS: TET2, SRSF2, SF3B1. (@TalhaBadarMD)
over 1 year ago
Next-generation sequencing
|
SF3B1 (Splicing Factor 3b Subunit 1) • TET2 (Tet Methylcytosine Dioxygenase 2) • SRSF2 (Serine and arginine rich splicing factor 2)
almost3years
Avapritinib now FDA-approved for adult pts with advanced systemic mastocytosis and its variants, incl. mast cell leukemia. Dose is lower (200 mg/day) than in PDGFRa-driven GIST. Early responses, good response rate and long-lasting disease control. Congratulations to Blueprint! (@schoffski)
almost 3 years ago
Clinical • FDA event
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PDGFRA (Platelet Derived Growth Factor Receptor Alpha)
|
Ayvakit (avapritinib)
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