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    DRUG:

    RMC-9805

    i
    Other names: RMC-9805, KRASG12D inhibitor, KRAS G12D inhibitor, RMC9805
    Company:
    Revolution Medicines
    Drug class:
    KRAS G12D inhibitor
    Related drugs:
    almost2years
    More to the RAS Story: Moving Beyond KRAS G12C Mutations in Lung Cancer talk by Colin R. Lindsay, #ASCO22 @OncoAlert KRASG12Di RMC-9805 binds to KRASG12D active form KRAS G12Vi RMC-also targets active form New way of targeting using cyclophilinA as a chaperone (@manjuggm)
    KRAS (KRAS proto-oncogene GTPase)
    |
    KRAS mutation • KRAS G12C • KRAS G12D • KRAS G12V • KRAS G12
    |
    RMC-9805
    2years
    #TTLC22 Important talk by Dr. @RielyMD on #KRAS G12D inhibition. Promising preclinical data for MRTX1133 and RMC-9805 (selective) as well as pan-KRAS inhibitors. Huge unmet need and look forward to seeing clinical results from these agents. #LCSM (@StephenVLiu)
    KRAS (KRAS proto-oncogene GTPase)
    |
    KRAS G12D
    |
    MRTX1133 • RMC-9805