KRAS G13

BI-2493 / BI-2865: non-covalent inhibitors, binding the inactive state of KRAS, blocked the activation of wild-type KRAS and a broad range of KRAS mutants, including G12A/C/D/F/V/S, G13C/D, V14I, L19F, Q22K, D33E, Q61H, K117N and A146V/T. @Boehringer #LCSM https://t.co/7m549MX20c (@HHorinouchi)

Very interesting! KRAS codon G12 mutations as a resistance biomarker on TAS102 for metastatic CRC? Pts with KRAS G13 codon mutations did better? @pashtoonkasi @GIcancerDoc @the_danielahn @IbrahimSahinMD1 @jonathanloree Comments? #CRCSM https://t.co/kRGjtmEmmp (@manjuggm)

Has anyone looked at kras G13 in pancreas cancer? ⁦@Aiims1742⁩ ⁦@DrJashDatta⁩ ⁦@NbmerchantMD⁩ ⁦@AndrewMWaters⁩ ⁦@krushnacpatra⁩ https://t.co/vW4suPAZ5U (@SyedAAhmad5)

Data presented by @tajiknia #AACRJCA22 shows MRTX1133 suppression of pERK at nM doses & synergies with 5-FU in CRC & pancreatic cancer cells with #KRAS G12D, G12V, & G13D. More studies needed before excluding non-G12D mutations from trials @BrownUCancer @BrownMedicine #eldeirylab https://t.co/DUlynIqYZH (@weldeiry)

Question that came up in our KRAS clinical trial group in @colontown. Does KRAS G13D mCRC respond differently to anti-EGFR abs? What papers show this? TY @pashtoonkasi @agrothey @doctorC369 (@manjuggm)

I guess not all of us agree with this abstract conclusions. How can cfDNA guide treatment decisions in adjuvant setting in 2020? It simply can not unless one believes exploratory analysis, not even done with same test. Remind me story with Kras G13D an anti-EGFR in mCRC... (@GarridoLagunaMD)

86 year old metastatic lung cancer with a malignant pleural effusion . Ecog Ps 0 PD L1 is 80 % Foundation 1 shows exon 14 met+ NF1+Nfkbia+ Tet2+Kras G13D+ RET What would be the first line treatment ? Pembro alone vs Capmatinib? @HosseinBorghaei @JackWestMD @PatelOncology (@BijoyTelivala)

Since the 💧#ptDNA [Peritoneal Tumor DNA] can be tested using simple & cost effective methods (Droplet digital PCR (ddPCR) using a commercially available screening kits, in 👆🏾it was a KRAS G12/G13 kit), it could be paired with some of the available🩸#ctDNA to ⬆️sensitivity.💡 (@pashtoonkasi)