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BIOMARKER:
KMT2D mutation
i
Other names:
KMT2D, Lysine Methyltransferase 2D, Histone-Lysine N-Methyltransferase 2D, Myeloid/Lymphoid Or Mixed-Lineage Leukemia 2, Lysine (K)-Specific Methyltransferase 2D, Trinucleotide Repeat Containing 21, Lysine N-Methyltransferase 2D, ALL1-Related Protein, MLL2, MLL4, ALR, Myeloid/Lymphoid Or Mixed-Lineage Leukemia Protein, Histone-Lysine N-Methyltransferase MLL2, Truncated Lysine Methyltransferase 2D, Kabuki Mental Retardation Syndrome, Kabuki Make-Up Syndrome, CAGL114, KABUK1, TNRC21, AAD10
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Entrez ID:
8085
Related biomarkers:
Expression
Mutation
Others
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Associations
(16)
News
Trials
Search handles
@AaronGoodman33
@jsoriamd
@michaelwangmd
Search handles
@AaronGoodman33
@jsoriamd
@michaelwangmd
Filter by
Latest
over1year
KMT2D is mutated in >20% of lung SCC. Kmt2d loss increases activation of RTKs, EGFR & ERBB2, driving a robust elevation in the oncogenic RTK-RAS signaling. Multiple therapeutic possibilities emerge from this finding. #LCSM #PrecisionMedicine https://t.co/asfbBkgfeE (@jsoriamd)
over 1 year ago
EGFR (Epidermal growth factor receptor) • HER-2 (Human epidermal growth factor receptor 2) • KMT2D (Lysine Methyltransferase 2D)
|
KMT2D mutation
over2years
Duodenal Follicular Lymphoma Remarkably indolent! Almost never experience extra-intestinal dz t(14;18) positive Exclusively grade 1-2 ⬇️KMT2D mutations compared to nodal ⬆️ EEF1A1, ⬆️HVCN1 mutations Chronic inflammatory gene signature Key paper https://t.co/jFAtUiIJwv (@AaronGoodman33)
over 2 years ago
KMT2D (Lysine Methyltransferase 2D) • EEF1A1 (Eukaryotic Translation Elongation Factor 1 Alpha 1)
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KMT2D mutation • Inflammatory gene signature
3years
Congratulations @JamesHeward88 @QMBCI on his manuscript @BloodJournal - KDM5 #epigenetic precision therapy in KMT2D mutated #lymphoma - compounds accessed from @thesgconline @GileadSciences @CPI_epigenetics Worth hearing about other methyltransferase inhibitors in development? (@fitzgi02)
3 years ago
KMT2D (Lysine Methyltransferase 2D)
|
KMT2D mutation
over3years
This study by Domenci et al, published in Nat. Genetics describes the effect of KMT2D haploinsufficiency and its impact on chromatin compartmentalization and nuclear architecture. KMT2D mutations are frequently observed in lymphomas. https://t.co/FaPXPvtdXl (@michaelwangmd)
over 3 years ago
KMT2D (Lysine Methyltransferase 2D)
|
KMT2D mutation
over3years
This is now the second tumor system (melanoma) after the previous paper (lung) showing that KMT2D mutants have metabolic deregulations: hyper glycolysis fueling the OXPHOS. Both by Kunal Rai. https://t.co/2BpKdWmgX5 (@michaelwangmd)
over 3 years ago
KMT2D (Lysine Methyltransferase 2D)
|
KMT2D mutation
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