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BIOMARKER:
KIT mutation
i
Other names:
KIT, C-Kit, CD117, PBT, SCFR, Stem Cell Factor Receptor, V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
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Entrez ID:
3815
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
Chr t(8;21) + KIT mutation (4)
Chr t(8;21)(q22;q22) + RUNX1-RUNX1T1 fusion + KIT exon 17 mutation + CSF3R mutation (4)
Chr t(8;21)(q22;q22) + RUNX1-RUNX1T1 fusion + KIT exon 17 mutation (3)
KIT P577del + KIT W557Lfs*5 + KIT Y823D (2)
Chr inv(16)t(16;16) + KIT mutation (1)
KIT wild-type + SDHB deletion (1)
RUNX1-RUNX1T1 fusion + KIT D816 (1)
Chr t(8;21) + KIT mutation (4)
Chr t(8;21)(q22;q22) + RUNX1-RUNX1T1 fusion + KIT exon 17 mutation + CSF3R mutation (4)
Chr t(8;21)(q22;q22) + RUNX1-RUNX1T1 fusion + KIT exon 17 mutation (3)
KIT P577del + KIT W557Lfs*5 + KIT Y823D (2)
Chr inv(16)t(16;16) + KIT mutation (1)
KIT wild-type + SDHB deletion (1)
RUNX1-RUNX1T1 fusion + KIT D816 (1)
›
Associations
(32)
News
Trials
Search handles
@JTrentMDPhD
@JasonSicklick
@UmutDisel
@hemedoc
Search handles
@JTrentMDPhD
@JasonSicklick
@UmutDisel
@hemedoc
Filter by
Latest
11ms
Thanks Dr Loghavi. So you will not typically see atypical mast cell aggregates in CBF AML with c-kit mutation? (@manupandey27)
11 months ago
KIT (KIT proto-oncogene, receptor tyrosine kinase)
|
KIT mutation
almost1year
•KIT/PDGFRA mutations in metastatic, imatinib-resistant #GIST •Prior Tx selects for resistant A-loop mutations •ctDNA resistance mutations prognosticate efficacy of 3rd/4th-line TKI @Annals_Oncology @DrCeSarcoma @SteveBialickDO @seppobauer S. George https://t.co/Mgzutsu317 (@JTrentMDPhD)
almost 1 year ago
Clinical • Circulating tumor DNA • Metastases
|
KIT (KIT proto-oncogene, receptor tyrosine kinase) • PDGFRA (Platelet Derived Growth Factor Receptor Alpha)
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KIT mutation • PDGFRA mutation
|
imatinib
1year
Practically I would be getting a BMT consult. Conceptually I get comfort from not transplanting favorable risk ELN because the CR2 rate is still high. Even Kit mutations make CBF AML less favorable, with del7, I’d be concerned (@TheDoctorIsVin)
1 year ago
KIT (KIT proto-oncogene, receptor tyrosine kinase)
|
KIT mutation
over1year
Molecularly matched therapy (MMT) was given in 2009 :) This is my first MMT case-thymic carcinoma with C-KIT mutation . (@UmutDisel)
over 1 year ago
Clinical
|
KIT (KIT proto-oncogene, receptor tyrosine kinase)
|
KIT mutation
over1year
#ASH22 #leusm Hyak: c-Kit mutations assoc w decreased DFS (and possibly OS) in CBF AML if VAF >10% but not if <10%. FLT3 and Ras mutations had no impact on survival outcomes. (@hemedoc)
over 1 year ago
FLT3 (Fms-related tyrosine kinase 3) • KIT (KIT proto-oncogene, receptor tyrosine kinase) • RAS (Rat Sarcoma Virus)
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KIT mutation • RAS mutation
over2years
Filip Janku, MD, PhD, discusses the phase 1 study with ripretinib in patients with KIT-mutated or KIT-amplified melanoma. @FilipJankuMD @UTHealthSAMDA #melsm https://t.co/0HDoC88Nm5 (@OncLive)
over 2 years ago
Clinical
|
KIT (KIT proto-oncogene, receptor tyrosine kinase)
|
KIT mutation
|
Qinlock (ripretinib)
over2years
The efficacy seen with ripretinib in patients with KIT-mutated melanoma was higher than has been previously reported @FilipJankuMD @UTHealthSAMDA #melsm https://t.co/AxIs2YBpl7 (@OncLive)
over 2 years ago
Clinical
|
KIT (KIT proto-oncogene, receptor tyrosine kinase)
|
KIT mutation
|
Qinlock (ripretinib)
over2years
Ripretinib Demonstrates Impressive Efficacy, Durability in Heavily Pretreated KIT-Mutated Melanoma @FilipJankuMD @UTHealthSAMDA #melsm https://t.co/ZRxXWkpXAZ (@OncLive)
over 2 years ago
Clinical
|
KIT (KIT proto-oncogene, receptor tyrosine kinase)
|
KIT mutation
|
Qinlock (ripretinib)
over2years
Clinical activity of ripretinib in patients with advanced gastrointestinal stromal tumor #GIST harboring heterogenous KIT/PDGFRA mutations @seppobauer @schoffski @jeanyvesblay @GinaDAmatoMD1 @SylvesterCancer https://t.co/rwLy6Gh01X (@JTrentMDPhD)
over 2 years ago
Clinical
|
KIT (KIT proto-oncogene, receptor tyrosine kinase) • PDGFRA (Platelet Derived Growth Factor Receptor Alpha)
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KIT mutation • PDGFRA mutation
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Qinlock (ripretinib)
over2years
Open @MDAndersonNews #ClinicalTrial #2021-0331 Study of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, Vs Placebo in Pts W/ Indolent Systemic Mastocytosis | PI: Prithviraj Bose @bose_prithviraj | NCT03731260 | https://t.co/JiwPVibHwR #leusm (@Lisa_Palacios)
over 2 years ago
Clinical
|
KIT (KIT proto-oncogene, receptor tyrosine kinase)
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KIT mutation
|
Ayvakit (avapritinib)
almost3years
Today is #GISTAwarenessDay. #GIST is a sarcoma of the GI tract. Despite common misbeliefs, this cancer is not always easily cured, treatment is not 1 size fits all, KIT mutations are not the only drivers, & it’s not as rare as we once believed. (@JasonSicklick)
almost 3 years ago
KIT (KIT proto-oncogene, receptor tyrosine kinase)
|
KIT mutation
almost3years
Thank you sir. These were my thoughts too. But, I wanted to recheck the literature once before commenting and found this nice article showing no adverse impact of c-kit mutation in children with t(8;21) AML. https://t.co/HI9fW9n7AV (@nitsoccer)
almost 3 years ago
KIT (KIT proto-oncogene, receptor tyrosine kinase)
|
KIT mutation
over3years
Ripretinib demonstrated clinically meaningful activity in patients with fourth-line or later advanced gastrointestinal stromal tumor and several, heterogeneous genetic subsets of KIT/PDGFRA mutations. @schoffski @KU_Leuven @ctosociety #CTOS2020 #scmsm https://t.co/rSSRzRCj66 (@OncLive)
over 3 years ago
Clinical
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PDGFRA (Platelet Derived Growth Factor Receptor Alpha)
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KIT mutation • PDGFRA mutation
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Qinlock (ripretinib)
over3years
Ripretinib Shows Antitumor Activity in Fourth-Line KIT/PDGFRA-Mutated Advanced GIST @schoffski @KU_Leuven #scmsm https://t.co/VfRXsIyFEk (@OncLive)
over 3 years ago
PDGFRA (Platelet Derived Growth Factor Receptor Alpha)
|
KIT mutation • PDGFRA mutation
|
Qinlock (ripretinib)
over3years
Our latest: RAS/MAPK Alterations Are Associated with KIT Mutations in Germ-cell Tumors and May Have Therapeutic Implications https://t.co/GHBSAdqC5S @MLadanyi @DrDarrenFeldman @jamalbenhamida @CDebyaniPhD (@DouglasMataMD)
over 3 years ago
KIT (KIT proto-oncogene, receptor tyrosine kinase)
|
KIT mutation
almost4years
A Comparison of Clinical and Molecular Characteristics of Patients With Systemic Mastocytosis With Chronic Myelomonocytic Leukemia to CMML Alone | Kit mutations are pathognomonic of SM| @sanamloghavi @DavidSteensma @HoratiuOlteanu https://t.co/DIwhBMZ7FI (@MrinalPatnaik)
almost 4 years ago
Clinical
|
KIT (KIT proto-oncogene, receptor tyrosine kinase)
|
KIT mutation
almost4years
NET not GIST. Only case reports of Glivec working in NETs with KIT mutations. (@SiBucz)
almost 4 years ago
Clinical
|
KIT (KIT proto-oncogene, receptor tyrosine kinase)
|
KIT mutation
|
imatinib
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