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BIOMARKER:
KIT mutation
i
Other names:
KIT, C-Kit, CD117, PBT, SCFR, Stem Cell Factor Receptor, V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
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Entrez ID:
3815
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
KIT exon 11 mutation (13)
KIT exon 9 mutation (9)
KIT N822K (7)
KIT D816V (6)
KIT exon 13 mutation (6)
KIT exon 17 mutation (6)
KIT L576P (5)
KIT T670I (4)
KIT D820Y (3)
KIT K642E (3)
KIT V559D (3)
KIT V654A (3)
KIT wild-type (3)
KIT S628N (2)
KIT W557_V559delinsF (2)
KIT exon 11 mutation + KIT exon 17 mutation (2)
KIT exon 18 mutation (2)
KIT exon 8 mutation (2)
BRAF G466V + KIT K509Q (1)
KDR Q472H + KIT M541L (1)
KIT A829P (1)
KIT D816G (1)
KIT D816H (1)
KIT D818Y (1)
KIT D820A (1)
KIT D820G (1)
KIT L576 (1)
KIT M541L (1)
KIT M552_V555delMYEV (1)
KIT N820Y (1)
KIT N822Y (1)
KIT V559A + KIT N822I (1)
KIT V559_E561del (1)
KIT V560E (1)
KIT V560G (1)
KIT W557_V559>C (1)
KIT W557_V559>F (1)
KIT Y823D (1)
KIT exon 11 W557_K558delins (1)
KIT exon 14 mutation (1)
KIT exon 17 mutation + KIT exon 18 mutation (1)
KIT translocation (1)
NR4A3 rearrangement + KIT mutation (1)
KIT D820E (0)
KIT K509Q (0)
KIT N822I (0)
KIT V559 (0)
KIT V559A (0)
KIT V560D (0)
KIT W557 (0)
KIT rs3733542 (0)
KIT exon 11 mutation (13)
KIT exon 9 mutation (9)
KIT N822K (7)
KIT D816V (6)
KIT exon 13 mutation (6)
KIT exon 17 mutation (6)
KIT L576P (5)
KIT T670I (4)
KIT D820Y (3)
KIT K642E (3)
KIT V559D (3)
KIT V654A (3)
KIT wild-type (3)
KIT S628N (2)
KIT W557_V559delinsF (2)
KIT exon 11 mutation + KIT exon 17 mutation (2)
KIT exon 18 mutation (2)
KIT exon 8 mutation (2)
BRAF G466V + KIT K509Q (1)
KDR Q472H + KIT M541L (1)
KIT A829P (1)
KIT D816G (1)
KIT D816H (1)
KIT D818Y (1)
KIT D820A (1)
KIT D820G (1)
KIT L576 (1)
KIT M541L (1)
KIT M552_V555delMYEV (1)
KIT N820Y (1)
KIT N822Y (1)
KIT V559A + KIT N822I (1)
KIT V559_E561del (1)
KIT V560E (1)
KIT V560G (1)
KIT W557_V559>C (1)
KIT W557_V559>F (1)
KIT Y823D (1)
KIT exon 11 W557_K558delins (1)
KIT exon 14 mutation (1)
KIT exon 17 mutation + KIT exon 18 mutation (1)
KIT translocation (1)
NR4A3 rearrangement + KIT mutation (1)
KIT D820E (0)
KIT K509Q (0)
KIT N822I (0)
KIT V559 (0)
KIT V559A (0)
KIT V560D (0)
KIT W557 (0)
KIT rs3733542 (0)
›
Associations
(32)
News
Trials
Search handles
@JTrentMDPhD
@JasonSicklick
@UmutDisel
@hemedoc
Search handles
@JTrentMDPhD
@JasonSicklick
@UmutDisel
@hemedoc
Filter by
Latest
11ms
Thanks Dr Loghavi. So you will not typically see atypical mast cell aggregates in CBF AML with c-kit mutation? (@manupandey27)
11 months ago
KIT (KIT proto-oncogene, receptor tyrosine kinase)
|
KIT mutation
almost1year
•KIT/PDGFRA mutations in metastatic, imatinib-resistant #GIST •Prior Tx selects for resistant A-loop mutations •ctDNA resistance mutations prognosticate efficacy of 3rd/4th-line TKI @Annals_Oncology @DrCeSarcoma @SteveBialickDO @seppobauer S. George https://t.co/Mgzutsu317 (@JTrentMDPhD)
almost 1 year ago
Clinical • Circulating tumor DNA • Metastases
|
KIT (KIT proto-oncogene, receptor tyrosine kinase) • PDGFRA (Platelet Derived Growth Factor Receptor Alpha)
|
KIT mutation • PDGFRA mutation
|
imatinib
1year
Practically I would be getting a BMT consult. Conceptually I get comfort from not transplanting favorable risk ELN because the CR2 rate is still high. Even Kit mutations make CBF AML less favorable, with del7, I’d be concerned (@TheDoctorIsVin)
1 year ago
KIT (KIT proto-oncogene, receptor tyrosine kinase)
|
KIT mutation
over1year
Molecularly matched therapy (MMT) was given in 2009 :) This is my first MMT case-thymic carcinoma with C-KIT mutation . (@UmutDisel)
over 1 year ago
Clinical
|
KIT (KIT proto-oncogene, receptor tyrosine kinase)
|
KIT mutation
over1year
#ASH22 #leusm Hyak: c-Kit mutations assoc w decreased DFS (and possibly OS) in CBF AML if VAF >10% but not if <10%. FLT3 and Ras mutations had no impact on survival outcomes. (@hemedoc)
over 1 year ago
FLT3 (Fms-related tyrosine kinase 3) • KIT (KIT proto-oncogene, receptor tyrosine kinase) • RAS (Rat Sarcoma Virus)
|
KIT mutation • RAS mutation
over2years
Filip Janku, MD, PhD, discusses the phase 1 study with ripretinib in patients with KIT-mutated or KIT-amplified melanoma. @FilipJankuMD @UTHealthSAMDA #melsm https://t.co/0HDoC88Nm5 (@OncLive)
over 2 years ago
Clinical
|
KIT (KIT proto-oncogene, receptor tyrosine kinase)
|
KIT mutation
|
Qinlock (ripretinib)
over2years
The efficacy seen with ripretinib in patients with KIT-mutated melanoma was higher than has been previously reported @FilipJankuMD @UTHealthSAMDA #melsm https://t.co/AxIs2YBpl7 (@OncLive)
over 2 years ago
Clinical
|
KIT (KIT proto-oncogene, receptor tyrosine kinase)
|
KIT mutation
|
Qinlock (ripretinib)
over2years
Ripretinib Demonstrates Impressive Efficacy, Durability in Heavily Pretreated KIT-Mutated Melanoma @FilipJankuMD @UTHealthSAMDA #melsm https://t.co/ZRxXWkpXAZ (@OncLive)
over 2 years ago
Clinical
|
KIT (KIT proto-oncogene, receptor tyrosine kinase)
|
KIT mutation
|
Qinlock (ripretinib)
over2years
Clinical activity of ripretinib in patients with advanced gastrointestinal stromal tumor #GIST harboring heterogenous KIT/PDGFRA mutations @seppobauer @schoffski @jeanyvesblay @GinaDAmatoMD1 @SylvesterCancer https://t.co/rwLy6Gh01X (@JTrentMDPhD)
over 2 years ago
Clinical
|
KIT (KIT proto-oncogene, receptor tyrosine kinase) • PDGFRA (Platelet Derived Growth Factor Receptor Alpha)
|
KIT mutation • PDGFRA mutation
|
Qinlock (ripretinib)
over2years
Open @MDAndersonNews #ClinicalTrial #2021-0331 Study of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, Vs Placebo in Pts W/ Indolent Systemic Mastocytosis | PI: Prithviraj Bose @bose_prithviraj | NCT03731260 | https://t.co/JiwPVibHwR #leusm (@Lisa_Palacios)
over 2 years ago
Clinical
|
KIT (KIT proto-oncogene, receptor tyrosine kinase)
|
KIT mutation
|
Ayvakit (avapritinib)
almost3years
Today is #GISTAwarenessDay. #GIST is a sarcoma of the GI tract. Despite common misbeliefs, this cancer is not always easily cured, treatment is not 1 size fits all, KIT mutations are not the only drivers, & it’s not as rare as we once believed. (@JasonSicklick)
almost 3 years ago
KIT (KIT proto-oncogene, receptor tyrosine kinase)
|
KIT mutation
almost3years
Thank you sir. These were my thoughts too. But, I wanted to recheck the literature once before commenting and found this nice article showing no adverse impact of c-kit mutation in children with t(8;21) AML. https://t.co/HI9fW9n7AV (@nitsoccer)
almost 3 years ago
KIT (KIT proto-oncogene, receptor tyrosine kinase)
|
KIT mutation
over3years
Ripretinib demonstrated clinically meaningful activity in patients with fourth-line or later advanced gastrointestinal stromal tumor and several, heterogeneous genetic subsets of KIT/PDGFRA mutations. @schoffski @KU_Leuven @ctosociety #CTOS2020 #scmsm https://t.co/rSSRzRCj66 (@OncLive)
over 3 years ago
Clinical
|
PDGFRA (Platelet Derived Growth Factor Receptor Alpha)
|
KIT mutation • PDGFRA mutation
|
Qinlock (ripretinib)
over3years
Ripretinib Shows Antitumor Activity in Fourth-Line KIT/PDGFRA-Mutated Advanced GIST @schoffski @KU_Leuven #scmsm https://t.co/VfRXsIyFEk (@OncLive)
over 3 years ago
PDGFRA (Platelet Derived Growth Factor Receptor Alpha)
|
KIT mutation • PDGFRA mutation
|
Qinlock (ripretinib)
over3years
Our latest: RAS/MAPK Alterations Are Associated with KIT Mutations in Germ-cell Tumors and May Have Therapeutic Implications https://t.co/GHBSAdqC5S @MLadanyi @DrDarrenFeldman @jamalbenhamida @CDebyaniPhD (@DouglasMataMD)
over 3 years ago
KIT (KIT proto-oncogene, receptor tyrosine kinase)
|
KIT mutation
almost4years
A Comparison of Clinical and Molecular Characteristics of Patients With Systemic Mastocytosis With Chronic Myelomonocytic Leukemia to CMML Alone | Kit mutations are pathognomonic of SM| @sanamloghavi @DavidSteensma @HoratiuOlteanu https://t.co/DIwhBMZ7FI (@MrinalPatnaik)
almost 4 years ago
Clinical
|
KIT (KIT proto-oncogene, receptor tyrosine kinase)
|
KIT mutation
almost4years
NET not GIST. Only case reports of Glivec working in NETs with KIT mutations. (@SiBucz)
almost 4 years ago
Clinical
|
KIT (KIT proto-oncogene, receptor tyrosine kinase)
|
KIT mutation
|
imatinib
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