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BIOMARKER:
IKZF1 deletion
i
Other names:
IKZF1, IKAROS Family Zinc Finger 1, Zinc Finger Protein Subfamily 1A 1 (Ikaros), Protein Phosphatase 1 Regulatory Subunit 92, Ikaros Family Zinc Finger Protein 1, Lymphoid Transcription Factor LyF-1, DNA-Binding Protein Ikaros, ZNFN1A1, IKAROS, LYF1, IK1, IKAROS Family Zinc Finger 1 (Ikaros), CLL-Associated Antigen KW-6, Hs.54452, PPP1R92, PRO0758, CVID13, LyF-1
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Entrez ID:
10320
Related biomarkers:
Expression
Mutation
CNA
‹
IKZF1 G151A overexpression (1)
IKZF1 overexpression (1)
IKZF1 G151A overexpression (1)
IKZF1 overexpression (1)
›
Associations
(5)
News
Trials
Search handles
@hemedoc
Search handles
@hemedoc
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Latest
almost2years
#ASH22 #leusm Pieters: Dutch ALL11 (peds age <=18) protocol decreased IKZF1del relapse risk 2.9 fold with 3 vs 2yr maintenance. (@hemedoc)
almost 2 years ago
Clinical
|
IKZF1 (IKAROS Family Zinc Finger 1)
|
IKZF1 deletion
almost2years
#ASH22 #leusm Boissel: Blin during consolidation (start wk12) in high risk B-ALL (KMT2Ar or IKZF1del or MRD>10e-4) — GRAAL2014/B QUEST substudy. Internal control cohort of 104 pts before addition of QUEST (Blin) substudy. Bridge to allo in MRD >10e-3 at EOI or >10e-4 at wk12. (@hemedoc)
almost 2 years ago
Clinical
|
KMT2A (Lysine Methyltransferase 2A) • IKZF1 (IKAROS Family Zinc Finger 1)
|
IKZF1 deletion
over2years
#EHA22 #leusm Clappier: MRD assessment in Ph pos ALL using BCR-ABL PCR req special scrutiny due to possibility of discrepant results between this and other methods. GRAALL studied BCR-ABL vs IgTCR PCR or IKZF1 del PCR and found frequent pos BCR-ABL but neg IgTCR. (@hemedoc)
over 2 years ago
ABL1 (ABL proto-oncogene 1) • BCR (BCR Activator Of RhoGEF And GTPase) • IKZF1 (IKAROS Family Zinc Finger 1)
|
IKZF1 deletion
almost4years
#ASH20 #leusm Sasaki: IZKF1del can be subtyped by site of deletion, which lead to either haploinsufficiency or dominant negative effect. 75% of IKZF1del have other copy number variatrions (they call IZKF1del plus). This subtype strongly associated with poor OS. (@hemedoc)
almost 4 years ago
IKZF1 (IKAROS Family Zinc Finger 1)
|
IKZF1 deletion
almost4years
#ASH20 #leusm Sasaki: Fascinating differences between Dasatinib v Ponatinib outcomes. Both vulnerable to IKZF1 plus, but Ponatinib overcomes risk of isolated IKZF1del. (@hemedoc)
almost 4 years ago
IKZF1 (IKAROS Family Zinc Finger 1)
|
IKZF1 deletion
|
dasatinib • Iclusig (ponatinib)
almost4years
#ASH20 #leusm Sasaki: IKZF1 deletions known to be risk for poor outcome in Ph+ ALL treated with imatinib or dasatinib. Pre-tx samples from 55 tx with hCVAD/Dasat and 50 tx with hCVAD/Ponat evaluated. IZKF1del found in 60%. (@hemedoc)
almost 4 years ago
IKZF1 (IKAROS Family Zinc Finger 1)
|
IKZF1 deletion
|
dasatinib • imatinib
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